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Streptococcus pneumoniae G54 (spne4)
Gene : sulD
DDBJ      :sulD         bifunctional folate synthesis protein
Swiss-Prot:SULD_STRR6   RecName: Full=Bifunctional folate synthesis protein;Includes:  RecName: Full=Dihydroneopterin aldolase;           Short=DHNA;           EC=4.1.2.25;Includes:  RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase;           EC=2.7.6.3;  AltName: Full=7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase;           Short=HPPK;  AltName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase;           Short=PPPK;

Homologs  Archaea  2/68 : Bacteria  734/915 : Eukaryota  113/199 : Viruses  0/175   --->[See Alignment]
d.58.30d.96.1
:270 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->267 2cg8C PDBj e-137 99.6 %
:RPS:PDB   1->267 2cg8A PDBj 2e-54 97.1 %
:RPS:SCOP  1->120 1dhnA  d.96.1.3 * 9e-30 26.7 %
:RPS:SCOP  120->268 1cbkA  d.58.30.1 * 9e-45 34.5 %
:HMM:SCOP  1->120 1dhnA_ d.96.1.3 * 3.2e-30 34.2 %
:HMM:SCOP  119->272 1cbkA_ d.58.30.1 * 2.1e-49 46.1 %
:RPS:PFM   6->102 PF02152 * FolB 1e-13 35.1 %
:RPS:PFM   123->248 PF01288 * HPPK 4e-29 50.8 %
:HMM:PFM   123->248 PF01288 * HPPK 3e-43 50.8 126/127  
:HMM:PFM   4->117 PF02152 * FolB 5.2e-27 32.7 113/113  
:BLT:SWISS 1->270 SULD_STRR6 e-156 99.6 %
:PROS 205->216|PS00794|HPPK

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF56325.1 GT:GENE sulD GT:PRODUCT bifunctional folate synthesis protein GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION 268055..268867 GB:FROM 268055 GB:TO 268867 GB:DIRECTION + GB:GENE sulD GB:PRODUCT bifunctional folate synthesis protein GB:NOTE identified by match to protein family HMM PF01288; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; match to protein family HMM TIGR01498 GB:PROTEIN_ID ACF56325.1 GB:DB_XREF GI:194357877 GB:GENE:GENE sulD LENGTH 270 SQ:AASEQ MDQLQIKDLEMFAYHGLFPSEKELGQKFVVSAILSYDMTKAATDLDLTASVHYGELCQQWTTWFQETSEDLIETVAYKLVERTFESYPLVQEMKLELKKPWAPVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLATEPWGGVEQDSFANQVVEVETWLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFVEDQILYTDDLILPHPYIAERLFVLESLQEIAPHFIHPILKQPIRNLYDALKK GT:EXON 1|1-270:0| SW:ID SULD_STRR6 SW:DE RecName: Full=Bifunctional folate synthesis protein;Includes: RecName: Full=Dihydroneopterin aldolase; Short=DHNA; EC=4.1.2.25;Includes: RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; EC=2.7.6.3; AltName: Full=7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; Short=HPPK; AltName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Short=PPPK; SW:GN Name=sulD; OrderedLocusNames=spr0269; SW:KW 3D-structure; ATP-binding; Complete proteome; Folate biosynthesis;Kinase; Lyase; Multifunctional enzyme; Nucleotide-binding;Transferase. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->270|SULD_STRR6|e-156|99.6|270/270| GO:SWS:NREP 7 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0046656|"GO:folic acid biosynthetic process"|Folate biosynthesis| GO:SWS GO:0016301|"GO:kinase activity"|Kinase| GO:SWS GO:0016829|"GO:lyase activity"|Lyase| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 205->216|PS00794|HPPK|PDOC00631| BL:PDB:NREP 1 BL:PDB:REP 1->267|2cg8C|e-137|99.6|248/248| RP:PDB:NREP 1 RP:PDB:REP 1->267|2cg8A|2e-54|97.1|240/240| RP:PFM:NREP 2 RP:PFM:REP 6->102|PF02152|1e-13|35.1|97/112|FolB| RP:PFM:REP 123->248|PF01288|4e-29|50.8|126/126|HPPK| HM:PFM:NREP 2 HM:PFM:REP 123->248|PF01288|3e-43|50.8|126/127|HPPK| HM:PFM:REP 4->117|PF02152|5.2e-27|32.7|113/113|FolB| GO:PFM:NREP 4 GO:PFM GO:0004150|"GO:dihydroneopterin aldolase activity"|PF02152|IPR006157| GO:PFM GO:0006760|"GO:folic acid and derivative metabolic process"|PF02152|IPR006157| GO:PFM GO:0003848|"GO:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"|PF01288|IPR000550| GO:PFM GO:0009396|"GO:folic acid and derivative biosynthetic process"|PF01288|IPR000550| RP:SCP:NREP 2 RP:SCP:REP 1->120|1dhnA|9e-30|26.7|120/121|d.96.1.3| RP:SCP:REP 120->268|1cbkA|9e-45|34.5|148/160|d.58.30.1| HM:SCP:REP 1->120|1dhnA_|3.2e-30|34.2|120/121|d.96.1.3|1/1|Tetrahydrobiopterin biosynthesis enzymes-like| HM:SCP:REP 119->272|1cbkA_|2.1e-49|46.1|154/0|d.58.30.1|1/1|6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK| OP:NHOMO 1023 OP:NHOMOORG 849 OP:PATTERN -------1---------1-------------------------------------------------- 111-22222221111111---111111111111111221112211-111112222212111-2211-22221---111111211111111211122----111111121111111111111111111211111211---11111-111111111111-1---121111-11--11-----1---1111111222222222222222222212222222212222122222222222222222222221111221--1--11-1-1111--1--1--1112222111122111111111112222222222222121222222212-111111111-1-21111111--1-12--11221221--221111111-1-1111-----111121121121122222222222-11111111121-111111111111221211------111111111111--11111111111111-----11-----------------1-111-11111111111111111111111111111-1111--1--1-11111111111-11111111111111-11111111111111111111111111-1111-11-1----1----------1-111-11111221112111111112111111111111-11121------11111111111111111-11111111111111111111111112111111111111111111111111111111111111111-1121111111112211111111111111111111111112111222121111111111---1--------1111111111112112211111111111111--111111-------------1----------------------11-1111111111 ----11------11111-11111-11111111111111111111--1111111111111111111111111111111-1111111111-11111111111111111-13-1-----------------------------------------------------------2----1-114---212233-221111111 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 270 STR:RPRED 100.0 SQ:SECSTR cEEEEEEEEEEEEcccccHHHHHHcEEEEEEEEEEEccHHHHHHTHHHHcccHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHcTTccEEEEEEEETTcccccccccEEEEEEEEcEEEEEEEEEccccHHHHHHHHHHHHHHTTcEEEEEcccccEcccccccccccEEEEEEEEEcccHHHHHHHHHHHHHHTTccccccccccccEEEEEEETTccccccccccccTTGGGcHHHHHHHHHHcTTcccTTTcccHHHHHTcGHE DISOP:02AL 270-271| PSIPRED ccEEEEEEEEEEEEEcccHHHHHcccEEEEEEEEEEccHHccccccHHHcccHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHcccccEEEEEEEEccccccccccEEEEEEEccccEEEEEEccccHHHHHHHHHHHHHHHHcccEEEEEcccccccccccccccccEEEEEEEEEcccHHHHHHHHHHHHHHHccccccccccccEEEEEEEEccEEEcccccEEccHHHHccHHHHHHHHHcccccccccccccHHHHHHHccc //