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Streptococcus pneumoniae G54 (spne4)
Gene : topA
DDBJ      :topA         DNA topoisomerase I
Swiss-Prot:             

Homologs  Archaea  66/68 : Bacteria  902/915 : Eukaryota  183/199 : Viruses  1/175   --->[See Alignment]
e.10.1g.41.3g.54.1
:695 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   16->558 1cy0A PDBj e-123 45.5 %
:RPS:PDB   16->558 1eclA PDBj e-166 46.2 %
:RPS:PDB   616->691 3a43A PDBj 3e-13 27.1 %
:RPS:SCOP  16->558 1cy0A  e.10.1.1 * e-158 46.1 %
:RPS:SCOP  572->625 1yuaA1  g.41.3.3 * 3e-16 25.9 %
:RPS:SCOP  620->674 1nltA3  g.54.1.1 * 1e-09 18.2 %
:RPS:SCOP  661->692 1i3qI1  g.41.3.1 * 2e-07 28.1 %
:HMM:SCOP  13->593 1mw9X_ e.10.1.1 * 6.1e-195 44.2 %
:RPS:PFM   16->102 PF01751 * Toprim 3e-13 43.7 %
:RPS:PFM   138->550 PF01131 * Topoisom_bac 3e-94 46.1 %
:RPS:PFM   579->616 PF01396 * zf-C4_Topoisom 3e-10 50.0 %
:RPS:PFM   619->653 PF01396 * zf-C4_Topoisom 7e-05 42.9 %
:HMM:PFM   138->550 PF01131 * Topoisom_bac 1.2e-131 40.8 390/404  
:HMM:PFM   581->615 PF01396 * zf-C4_Topoisom 7e-17 42.9 35/39  
:HMM:PFM   620->658 PF01396 * zf-C4_Topoisom 3.2e-16 40.5 37/39  
:HMM:PFM   14->121 PF01751 * Toprim 3.5e-29 42.1 95/96  
:HMM:PFM   663->693 PF02150 * RNA_POL_M_15KD 0.00011 41.4 29/35  
:BLT:SWISS 15->695 TOP1_LACLA 0.0 81.2 %
:PROS 290->312|PS00396|TOPOISOMERASE_I_PROK
:REPEAT 2|599->636|641->676
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF54979.1 GT:GENE topA GT:PRODUCT DNA topoisomerase I GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION complement(1129810..1131897) GB:FROM 1129810 GB:TO 1131897 GB:DIRECTION - GB:GENE topA GB:PRODUCT DNA topoisomerase I GB:NOTE identified by match to protein family HMM PF01131; match to protein family HMM PF01396; match to protein family HMM PF01751; match to protein family HMM TIGR01051 GB:PROTEIN_ID ACF54979.1 GB:DB_XREF GI:194356531 GB:GENE:GENE topA LENGTH 695 SQ:AASEQ MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNDEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKIK GT:EXON 1|1-695:0| BL:SWS:NREP 1 BL:SWS:REP 15->695|TOP1_LACLA|0.0|81.2|681/710| PROS 290->312|PS00396|TOPOISOMERASE_I_PROK|PDOC00333| NREPEAT 1 REPEAT 2|599->636|641->676| SEG 2->14|atatkkkkstvkk| SEG 559->570|kevakaeeemek| BL:PDB:NREP 1 BL:PDB:REP 16->558|1cy0A|e-123|45.5|527/534| RP:PDB:NREP 2 RP:PDB:REP 16->558|1eclA|e-166|46.2|524/552| RP:PDB:REP 616->691|3a43A|3e-13|27.1|70/138| RP:PFM:NREP 4 RP:PFM:REP 16->102|PF01751|3e-13|43.7|87/110|Toprim| RP:PFM:REP 138->550|PF01131|3e-94|46.1|401/407|Topoisom_bac| RP:PFM:REP 579->616|PF01396|3e-10|50.0|38/39|zf-C4_Topoisom| RP:PFM:REP 619->653|PF01396|7e-05|42.9|33/39|zf-C4_Topoisom| HM:PFM:NREP 5 HM:PFM:REP 138->550|PF01131|1.2e-131|40.8|390/404|Topoisom_bac| HM:PFM:REP 581->615|PF01396|7e-17|42.9|35/39|zf-C4_Topoisom| HM:PFM:REP 620->658|PF01396|3.2e-16|40.5|37/39|zf-C4_Topoisom| HM:PFM:REP 14->121|PF01751|3.5e-29|42.1|95/96|Toprim| HM:PFM:REP 663->693|PF02150|0.00011|41.4|29/35|RNA_POL_M_15KD| GO:PFM:NREP 12 GO:PFM GO:0003677|"GO:DNA binding"|PF01131|IPR013497| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01131|IPR013497| GO:PFM GO:0005694|"GO:chromosome"|PF01131|IPR013497| GO:PFM GO:0006265|"GO:DNA topological change"|PF01131|IPR013497| GO:PFM GO:0003677|"GO:DNA binding"|PF01396|IPR013498| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01396|IPR013498| GO:PFM GO:0005694|"GO:chromosome"|PF01396|IPR013498| GO:PFM GO:0006265|"GO:DNA topological change"|PF01396|IPR013498| GO:PFM GO:0003677|"GO:DNA binding"|PF01396|IPR013498| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01396|IPR013498| GO:PFM GO:0005694|"GO:chromosome"|PF01396|IPR013498| GO:PFM GO:0006265|"GO:DNA topological change"|PF01396|IPR013498| RP:SCP:NREP 4 RP:SCP:REP 16->558|1cy0A|e-158|46.1|527/534|e.10.1.1| RP:SCP:REP 572->625|1yuaA1|3e-16|25.9|54/65|g.41.3.3| RP:SCP:REP 620->674|1nltA3|1e-09|18.2|55/74|g.54.1.1| RP:SCP:REP 661->692|1i3qI1|2e-07|28.1|32/49|g.41.3.1| HM:SCP:REP 13->593|1mw9X_|6.1e-195|44.2|557/0|e.10.1.1|1/1|Prokaryotic type I DNA topoisomerase| OP:NHOMO 1995 OP:NHOMOORG 1152 OP:PATTERN 333333323333333322222222111111111112211111111111122223222222211123-- 1121111111111111111-11111111111111111111111111111111111111111111111111111111221121231322444412341--1131112221211111111111111111111111111111111111132321111111111111111222211111111111111111222112234346343334434332222243413422221222223332222221232222222222311111211111211112211121111141122111111111111111111111121111111111111123333333334333326333333131232232133341211121122112111111111111111111112111111111111111-11112112112111111111111111111111111111111111111111111111111111111111111111111111111111111111116111112211111111111111152121211111132512111112111112111211111121411112111221122221111111111111121111111211311111232121111221333432323234334343333333333333331-111121--11133344333333333333-4333333333333333333334433454333433343443433533333223-333333333533--1111111111111123332333432323443211211111121122222331223311231111111111343333333433331121422111412211211111111111111111111111-111-1111111111111112112121222111 1122111-733111111111111111122111111111-121111111111111111-1111111111111-11111--111111111-1211-1111111-1212112142321212-1122163-3-8H2-322111122221-111122-42322223B2421-212322322233L2222343241333121111 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------1---- STR:NPRED 677 STR:RPRED 97.4 SQ:SECSTR ##############EEEEEccHHHHHHHHTTccTTEEEEEcccccEEcccHHHcEETTTTTEEccEEcTTTHHHHHHHHHHHHHccEEEEcccccHHHHHHHHHHHHHHcccGGGEEEcccccccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHTcTTccccTTHHHHHHHHHHHHHHHHTccccEEEEEEEEEEcTTccEEEEEEEETTEEcccccHHHHHHHHHHHHHccEEEEEEEEEEEEEcccccccHHHHHHHHHHHHcccHHHHHHHHHHHHHTTcTTGGGTTcccccccccccccHHHHHHHHHHHHHHTcGGGccccccccccccccccccccccccTTccGGGccccccHHHHHHHHHHHHHHHHHTcccEEEEEEEEEEEETTEEEEEEEEEEEEcGGGGTccccccccccccccTTcEEEEEEEEEEEEEccccccccHHHHHHHHHHTTcccTTTHHHHHHHHHHTTcEEEETTEEEEcHHHHHHHHHHHHHcHHHHcHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHTccGGGTcccccccccccGGGTcccEEEEEEEEEcccTTTcccccccEEEEEEEEEEEEcccEEcHHHHHTTcccEEEEccHHHHHHHHHHHHHHHHHHHHcTcTTTTccTTccHHHHTTEEEEccc#### DISOP:02AL 1-12,256-258,339-349,454-454,690-690,692-696| PSIPRED ccccccccccccccEEEEEccHHHHHHHHHHHccccEEEEEEccEEccccccccccHHHcccccEEEcccHHHHHHHHHHHHHHccEEEEccccccHHHHHHHHHHHHHccccccEEEEEEEcccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHcHHHHHHHccccccccccHHHHHHHHHHHHHHHcccccEEEEEEEEEEcccEEEEEEEEEccccccccccHHHHHHHHHHHccccEEEEEEEEcEEcccccccccHHHHHHHHHHHccccHHHHHHHHHHHHcccccccccEEEEEccccccccccHHHHHHHHHHHHHHHHHHHccccccccccccccccccccccccccccHHHHHHHccHHHHHHHHHHHHHHHHHHcccEEEEEEEEEEEEccEEEEEEEEEEEEcccHHHHccccccccccccccccEEEEEEEEEEEccccccccccHHHHHHHHHHccccccccHHHHHHHHHHcccEEEEccEEEEcHHHHHHHHHHHHHcHHHccHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccccEEEEEcccccEEEEccccccccccccccccccccccccccEEEEEccccccEEEEEcccccccccccccccccccccccccEEEEEcccccEEEEcccccccccccc //