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Thermobifida fusca YX (tfus0)
Gene : AAZ54641.1
DDBJ      :             NAD-dependent DNA ligase
Swiss-Prot:DNLJ_THEFY   RecName: Full=DNA ligase;         EC=6.5.1.2;AltName: Full=Polydeoxyribonucleotide synthase [NAD+];

Homologs  Archaea  6/68 : Bacteria  898/915 : Eukaryota  72/199 : Viruses  2/175   --->[See Alignment]
a.60.2b.40.4c.15.1d.142.2
:745 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   30->640 2owoA PDBj e-118 43.0 %
:BLT:PDB   636->729 2ebuA PDBj 3e-15 45.1 %
:RPS:PDB   27->727 1dgtB PDBj 0.0 44.2 %
:RPS:SCOP  33->341 1b04A  d.142.2.2 * 8e-81 49.0 %
:RPS:SCOP  341->422 1dgsA2  b.40.4.6 * 1e-15 54.9 %
:RPS:SCOP  427->645 1dgsA1  a.60.2.2 * 1e-31 35.6 %
:RPS:SCOP  626->728 1wf6A  c.15.1.5 * 2e-15 12.7 %
:HMM:SCOP  26->341 1b04A_ d.142.2.2 * 5.7e-116 53.7 %
:HMM:SCOP  340->425 1dgsA2 b.40.4.6 * 6.9e-28 57.0 %
:HMM:SCOP  426->645 1dgsA1 a.60.2.2 * 2e-52 47.5 %
:HMM:SCOP  647->728 1l7bA_ c.15.1.2 * 1.9e-18 44.4 %
:RPS:PFM   31->341 PF01653 * DNA_ligase_aden 5e-81 55.5 %
:RPS:PFM   345->424 PF03120 * DNA_ligase_OB 3e-16 57.5 %
:RPS:PFM   659->718 PF00533 * BRCT 4e-10 45.0 %
:HMM:PFM   30->341 PF01653 * DNA_ligase_aden 1.2e-121 51.3 308/315  
:HMM:PFM   344->423 PF03120 * DNA_ligase_OB 6.2e-34 58.8 80/82  
:HMM:PFM   651->720 PF00533 * BRCT 5.8e-14 37.7 69/78  
:HMM:PFM   430->457 PF03119 * DNA_ligase_ZBD 1.8e-12 55.6 27/28  
:HMM:PFM   593->621 PF00633 * HHH 4.1e-09 44.8 29/30  
:BLT:SWISS 1->745 DNLJ_THEFY 0.0 100.0 %
:PROS 137->166|PS01055|DNA_LIGASE_N1
:PROS 354->369|PS01056|DNA_LIGASE_N2

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAZ54641.1 GT:GENE AAZ54641.1 GT:PRODUCT NAD-dependent DNA ligase GT:DATABASE GIB00263CH01 GT:ORG tfus0 GB:ACCESSION GIB00263CH01 GB:LOCATION 692635..694872 GB:FROM 692635 GB:TO 694872 GB:DIRECTION + GB:PRODUCT NAD-dependent DNA ligase GB:PROTEIN_ID AAZ54641.1 GB:DB_XREF GI:71914739 InterPro:IPR000445 InterPro:IPR001357 InterPro:IPR001679 InterPro:IPR003583 LENGTH 745 SQ:AASEQ MRNHGPGSERKDACVSAPDPTFSDDVPADVRERHARLSQDLDDYSYRYYLGSPIISDAEYDQLMAELRDLEAQYPSLVTPDSPTQKVGAPISNEFAPVEHLERMQSLDNAFSDAQLEAWAHRVSAEVPVDAFLCELKIDGLAVALVYEKGRLVRAATRGDGRIGEDITLNIRTIDTVPLRLDESRYPAPELLEVRGEVFLPVKAFEQLNSRLADEGKPPFANPRNAAAGSLRQKDPRVTASRPLSMLVHGIGAHRGVTITHQSQSYELLAAWGLPVSDRIRVVSTLDEVREYIAYYAEHRHDPEYEIDGVVVKVDDVSLQRRLGSTSRAPRWAIAYKYPPEEVTTKLLDIKTSVGRTGRVTPYAVLEPVKVAGSEVEFATLHNAQEVARKGVLIGDTVVVRKAGDIIPEVVGPVVEKRTGTERPFVMPTECPECGSPLGQQKEGDVDLRCPNTRYCKGQLRERLAFIAGRKALDIEALGYVAATALTQPLEPAEPPLRDEGDLFSLTVEQLLPIRTLVLDPDTAEPKIDPKTGKPKVVSFFANQKGEPKKIVEKLFQQLEEAKKRPLWRVLVALSIRHVGPRAAEDLARHFRSLDAIAQASEEELEAVEGIGPTIARSIVDWFSVDWHREIVEKWRAAGVRMEEEGADDGPRLLDGITTVITGTLEKYSRDGAKEAVQKLGGRVTGSVSRKTDFVVVGANPGSKYDKAVKLGVPILDEAGFEVLLTQGPEAARAARLSEDESVLS GT:EXON 1|1-745:0| SW:ID DNLJ_THEFY SW:DE RecName: Full=DNA ligase; EC=6.5.1.2;AltName: Full=Polydeoxyribonucleotide synthase [NAD+]; SW:GN Name=ligA; OrderedLocusNames=Tfu_0603; SW:KW Complete proteome; DNA damage; DNA repair; DNA replication; Ligase;Magnesium; Manganese; Metal-binding; NAD; Zinc. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->745|DNLJ_THEFY|0.0|100.0|745/745| GO:SWS:NREP 5 GO:SWS GO:0006974|"GO:response to DNA damage stimulus"|DNA damage| GO:SWS GO:0006281|"GO:DNA repair"|DNA repair| GO:SWS GO:0006260|"GO:DNA replication"|DNA replication| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| PROS 137->166|PS01055|DNA_LIGASE_N1|PDOC00809| PROS 354->369|PS01056|DNA_LIGASE_N2|PDOC00809| BL:PDB:NREP 2 BL:PDB:REP 30->640|2owoA|e-118|43.0|572/586| BL:PDB:REP 636->729|2ebuA|3e-15|45.1|91/112| RP:PDB:NREP 1 RP:PDB:REP 27->727|1dgtB|0.0|44.2|652/660| RP:PFM:NREP 3 RP:PFM:REP 31->341|PF01653|5e-81|55.5|308/314|DNA_ligase_aden| RP:PFM:REP 345->424|PF03120|3e-16|57.5|80/82|DNA_ligase_OB| RP:PFM:REP 659->718|PF00533|4e-10|45.0|60/76|BRCT| HM:PFM:NREP 5 HM:PFM:REP 30->341|PF01653|1.2e-121|51.3|308/315|DNA_ligase_aden| HM:PFM:REP 344->423|PF03120|6.2e-34|58.8|80/82|DNA_ligase_OB| HM:PFM:REP 651->720|PF00533|5.8e-14|37.7|69/78|BRCT| HM:PFM:REP 430->457|PF03119|1.8e-12|55.6|27/28|DNA_ligase_ZBD| HM:PFM:REP 593->621|PF00633|4.1e-09|44.8|29/30|HHH| GO:PFM:NREP 5 GO:PFM GO:0003911|"GO:DNA ligase (NAD+) activity"|PF01653|IPR013839| GO:PFM GO:0003911|"GO:DNA ligase (NAD+) activity"|PF03120|IPR004150| GO:PFM GO:0006260|"GO:DNA replication"|PF03120|IPR004150| GO:PFM GO:0006281|"GO:DNA repair"|PF03120|IPR004150| GO:PFM GO:0005622|"GO:intracellular"|PF00533|IPR001357| RP:SCP:NREP 4 RP:SCP:REP 33->341|1b04A|8e-81|49.0|302/310|d.142.2.2| RP:SCP:REP 341->422|1dgsA2|1e-15|54.9|82/86|b.40.4.6| RP:SCP:REP 427->645|1dgsA1|1e-31|35.6|180/181|a.60.2.2| RP:SCP:REP 626->728|1wf6A|2e-15|12.7|102/132|c.15.1.5| HM:SCP:REP 26->341|1b04A_|5.7e-116|53.7|311/312|d.142.2.2|1/1|DNA ligase/mRNA capping enzyme, catalytic domain| HM:SCP:REP 340->425|1dgsA2|6.9e-28|57.0|86/86|b.40.4.6|1/1|Nucleic acid-binding proteins| HM:SCP:REP 426->645|1dgsA1|2e-52|47.5|181/181|a.60.2.2|1/1|RuvA domain 2-like| HM:SCP:REP 647->728|1l7bA_|1.9e-18|44.4|81/92|c.15.1.2|1/1|BRCT domain| OP:NHOMO 1085 OP:NHOMOORG 978 OP:PATTERN ------------------------1--11111------------------------------------ 1111111111111111-11-11111111111111112111111111111111121111111111211122111111111111111111111111111--1111111111111111111111111111111121111111111111112111121111111111121111111111---1-11-21111--111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111121111111111111111111111111111111111111111111111111111111111111111111111111111111111-11112111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111112111111111111111111111111111111111111111111111211112111111112111111111111111111-11111-1111122221222111211112-122111121111222222111122221222222222221212111-1111111222222222222111111111111111121111111111111111111111111121111121222222222121111111111111111111111111111111111111111111111111111111111111111-11111111111111211111111111111121 -1--11--------------------------------------------------------1-------1---------------1-------1-1-1-----111---111111211--11-1211-251-112-111211-1111-12--212111--2111-1------11-212B111--2121-1-12----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------1---------1---- STR:NPRED 712 STR:RPRED 95.6 SQ:SECSTR ##########################GGGHHHHHHHHHHHHHHHHHHHHTccccccTTHHHHHHHHHHHHHHHcGGGccTTcGGGccTTcccccccEEEcccccccccEEccHHHHHHHHHTTcccccccEEEEEEEcccEEEEEEEETTEEEEEEEcccccEEEccHHHHTTcTTccccccccccccccEEEEEEEEEccHHHHHHHHHHHHTTTccccccHHHHHHHHHccccTHHHHccccEEEEEEEccccccccccHHHHHHHHHHHTccccccEEEEEHHHHHHHHHHHHHHTGGGccccccEEEEEEccGGGTTTccccccccccEEEEEccccEEEEEccEEEEEEcTTccEEEEEEEEEEEccccEEEEEEccccTTTTTTTccTTcEEEEEcTTccccEEEEEcTTcccccccccccccccTTTccHHHcccccccccccccTcTcTTcHHHHHHHHccTTccccTTccHHHHHHHHTTTccccTTTTcccTTcccccHHHHTTTTEEEEEcccGGGTTcTTEEEcccccccTTcccccHHHHHHHHHHHTGGGccHHHHHHHHTcTTccTTHHHHHHHHHccHHHHHTccHHHHcccccccHHHHHHHHHHHHcHHHHHHHHHHHTTTccccccHHcccccTTcccccccccccccccTTHHHHcccccccccccccccccccccccTTTcccccccTTTccccccccccTTTTTcTHccHHHHHHH####### DISOP:02AL 1-28, 728-740| PSIPRED cccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHccccccccccccccccHHHccccccccccccccHHHcccHHHHHHHHHHHHHHcccccEEEEEccccEEEEEEEEccEEEEEEEcccccccccHHHHHHHHHHHHHHccccccccccEEEEEEEEEEcHHHHHHHHHHHHHHcccccccHHHHHHHHHHcccccHHHHccccEEEEEEccccccccccHHHHHHHHHHcccccccccEEEccHHHHHHHHHHHHHHcccccccccEEEEEEccHHHHHHHccccccccEEEEEcccccEEEEEEEEEEEEEcccEEEEEEEEEEEEEEccEEEEEEEcccHHHHHHcccccccEEEEEEcccccHHHHHHHHcccccccccEEcccccccccccccccccccEEEEcccccccHHHHHHHHHHHHcccccccccccHHHHHHHHHHHcccccccccHHHHHcccHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHcccHHHHHHHcccccccHHHHHHHHHHcccHHHHHHccHHHHHHcccccHHHHHHHHHHHHcccHHHHHHHHHHccccccccccccccccccccEEEEEEEEccccHHHHHHHHHHcccEEEEcccccccEEEEcccccHHHHHHHHcccEEEcHHHHHHHHHHHHHHHHHHHHHHHHHHcc //