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Thermobifida fusca YX (tfus0)
Gene : AAZ55146.1
DDBJ      :             UDP-N-acetylmuramoylalanine--D-glutamate ligase
Swiss-Prot:MURD_THEFY   RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase;         EC=6.3.2.9;AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase;AltName: Full=D-glutamic acid-adding enzyme;

Homologs  Archaea  1/68 : Bacteria  820/915 : Eukaryota  6/199 : Viruses  0/175   --->[See Alignment]
c.5.1c.59.1c.72.2
:465 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   2->463 1uagA PDBj 4e-21 29.1 %
:RPS:PDB   4->76 2aemA PDBj 2e-05 13.7 %
:RPS:PDB   54->465 1e8cB PDBj 4e-31 12.8 %
:RPS:SCOP  8->94 1j6uA1  c.5.1.1 * 1e-07 25.9 %
:RPS:SCOP  97->316 1e0dA3  c.72.2.1 * 2e-21 24.1 %
:RPS:SCOP  320->464 1e0dA2  c.59.1.1 * 4e-24 30.4 %
:HMM:SCOP  1->96 2uagA1 c.5.1.1 * 5.8e-22 46.7 %
:HMM:SCOP  99->316 2uagA3 c.72.2.1 * 3.8e-51 38.1 %
:HMM:SCOP  318->464 2uagA2 c.59.1.1 * 5.2e-37 45.3 %
:RPS:PFM   114->245 PF08245 * Mur_ligase_M 3e-07 38.8 %
:HMM:PFM   114->299 PF08245 * Mur_ligase_M 2.9e-41 42.4 170/188  
:HMM:PFM   320->388 PF02875 * Mur_ligase_C 1.2e-07 25.0 68/91  
:HMM:PFM   8->60 PF02737 * 3HCDH_N 7.9e-05 26.4 53/180  
:BLT:SWISS 1->465 MURD_THEFY 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAZ55146.1 GT:GENE AAZ55146.1 GT:PRODUCT UDP-N-acetylmuramoylalanine--D-glutamate ligase GT:DATABASE GIB00263CH01 GT:ORG tfus0 GB:ACCESSION GIB00263CH01 GB:LOCATION 1292046..1293443 GB:FROM 1292046 GB:TO 1293443 GB:DIRECTION + GB:PRODUCT UDP-N-acetylmuramoylalanine--D-glutamate ligase GB:PROTEIN_ID AAZ55146.1 GB:DB_XREF GI:71915244 InterPro:IPR001645 InterPro:IPR005762 LENGTH 465 SQ:AASEQ MELRGRRVCVTGLGVSGPPVARALLKHGAHVTVVEGRDDDVNRERARTLRELGATVELGEPTTLPAGTDLVVTSPGWRPDAPVLVAAADAGVEVIGDVELAWRLRPAGQVWLAVTGTNGKTTTVRMLEAMLRADGRRALAVGNVGTPVIDAALADGPDRWDILAVELSSFQLHWSATVQPHAAAIINLAPDHLDWHGGMEPYAAAKAKVYGAGTIRIVNAADPALRELAETHGDPAAPLVGFSLDVPRAGELGLVEDLLVDRAFVANPRTEATELATLADVTPRAPHNVANALAAAALARSIGVAPEAVRTGLRNFQPEPHRIAHVATIDGVDYVDDSKATNAHAAAASLAAYPSVVWIAGGLLKGADVTGLVRQAASRLRGVVLLGADRHQLREALDTHAPHVPVVDVARTDEGAMAEVVAAAARLAQKGDTVLLAPAAASMDMFTNYIERGEAFAREVRALAG GT:EXON 1|1-465:0| SW:ID MURD_THEFY SW:DE RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase; EC=6.3.2.9;AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase;AltName: Full=D-glutamic acid-adding enzyme; SW:GN Name=murD; OrderedLocusNames=Tfu_1108; SW:KW ATP-binding; Cell cycle; Cell division; Cell shape;Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;Ligase; Nucleotide-binding; Peptidoglycan synthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->465|MURD_THEFY|0.0|100.0|465/465| GO:SWS:NREP 9 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0007049|"GO:cell cycle"|Cell cycle| GO:SWS GO:0051301|"GO:cell division"|Cell division| GO:SWS GO:0008360|"GO:regulation of cell shape"|Cell shape| GO:SWS GO:0007047|"GO:cellular cell wall organization"|Cell wall biogenesis/degradation| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0009252|"GO:peptidoglycan biosynthetic process"|Peptidoglycan synthesis| SEG 79->90|pdapvlvaaada| SEG 202->213|yaaakakvygag| SEG 290->299|analaaaala| SEG 340->352|atnahaaaaslaa| SEG 416->428|amaevvaaaarla| BL:PDB:NREP 1 BL:PDB:REP 2->463|1uagA|4e-21|29.1|422/427| RP:PDB:NREP 2 RP:PDB:REP 4->76|2aemA|2e-05|13.7|73/226| RP:PDB:REP 54->465|1e8cB|4e-31|12.8|398/484| RP:PFM:NREP 1 RP:PFM:REP 114->245|PF08245|3e-07|38.8|129/187|Mur_ligase_M| HM:PFM:NREP 3 HM:PFM:REP 114->299|PF08245|2.9e-41|42.4|170/188|Mur_ligase_M| HM:PFM:REP 320->388|PF02875|1.2e-07|25.0|68/91|Mur_ligase_C| HM:PFM:REP 8->60|PF02737|7.9e-05|26.4|53/180|3HCDH_N| GO:PFM:NREP 2 GO:PFM GO:0005524|"GO:ATP binding"|PF08245|IPR013221| GO:PFM GO:0009058|"GO:biosynthetic process"|PF08245|IPR013221| RP:SCP:NREP 3 RP:SCP:REP 8->94|1j6uA1|1e-07|25.9|81/89|c.5.1.1| RP:SCP:REP 97->316|1e0dA3|2e-21|24.1|195/196|c.72.2.1| RP:SCP:REP 320->464|1e0dA2|4e-24|30.4|135/140|c.59.1.1| HM:SCP:REP 1->96|2uagA1|5.8e-22|46.7|92/93|c.5.1.1|1/1|MurCD N-terminal domain| HM:SCP:REP 99->316|2uagA3|3.8e-51|38.1|202/204|c.72.2.1|1/1|MurD-like peptide ligases, catalytic domain| HM:SCP:REP 318->464|2uagA2|5.2e-37|45.3|137/140|c.59.1.1|1/1|MurD-like peptide ligases, peptide-binding domain| OP:NHOMO 832 OP:NHOMOORG 827 OP:PATTERN ----------------------------------1--------------------------------- 1112111111111111111-1111111111111111111111111111111111111111--1111111111111111111111111-111111111--1111111111111111111111111111111111111-11-1-----111111111--1111111111111111111111111111111--12111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-11111111111111111111111111111111-11-111111111111111111111111111111111-111111111111111111111111111111111111111111111111--1111111----------111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-----11111----------11-11111111111111111111111111111111111-1111111-11111111111111111111-1111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-1111111111111111111-11----------------------------------------1111111111-11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1---1------2--1--2--1---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 465 STR:RPRED 100.0 SQ:SECSTR cccTTccEEEEcccccHHHHHHHHTcccccTTccccccccEEcGcGGGccTTccTTTccTTcEEETTEEEEEETTHHHHHHHHHTTcGGGccEEEEEEccccHHHHHHHHEHHHHHHTTccEEEcTTccEETTcccccccccccHHHHHHHHHHHHHHTTccEEEEccHHHHHTTTTccccEEEEcccccccHHHHccHHHHHHHHHHHcccccEEEEETTcHHHHHHHTTccccTTcEEEEcccccTTTccEEEEEEEEEEccccEEEEEEETTccEEEEEcccHHHHHHHHHHHHHHHHTTccHHHHHHHGGGccccTTcEEEccTTccEEEEEcccHHHHHHHHHHTccccEEEEEccccccccTHHHHHHHHHHHccEEEEcTccHHHHHHHHHHTTccTTccEEccHHHcTHHHHHHHHHHHccTTcEEEEEcEccTTccEEEETTEEEEccHHHHHHHH DISOP:02AL 465-466| PSIPRED ccccccEEEEEcccHHHHHHHHHHHHcccEEEEEEcccccccHHHHHHHHHcccEEEEcccHHHHccccEEEEccccccccHHHHHHHHcccccccHHHHHHHHcccccEEEEEEcccccHHHHHHHHHHHHHccccEEEEccccHHHHHHHHHcccccEEEEEEccccccHHHHHccccEEEEEccccHHHHHHcccHHHHHHHHHHHHccccEEEEEcccHHHHHHHHHHHccccEEEEEcccccccccHHHccccEEccEEEEEEEccccccccccccccccHHHHHHHHHHHHHHHHccccHHHHHHHHHHcccccccEEEEEcccEEEEEEccccccHHHHHHHHHHcccEEEEEEcccccccHHHHHHHHHHcccEEEEEccccHHHHHHHHHHcccccccccccEEEccHHHHHHHHHHHcccccEEEEEccccHHHHcccHHHHHHHHHHHHHHHcc //