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Thermotoga maritima MSB8 (tmar0)
Gene : AAD35266.1
DDBJ      :             reverse gyrase
Swiss-Prot:RGYR_THEMA   RecName: Full=Reverse gyrase;Includes:  RecName: Full=Helicase;           EC=3.6.1.-;Includes:  RecName: Full=Topoisomerase;           EC=5.99.1.3;

Homologs  Archaea  55/68 : Bacteria  833/915 : Eukaryota  30/199 : Viruses  1/175   --->[See Alignment]
c.37.1e.10.1
:1104 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   46->1100 1gl9C PDBj e-166 40.0 %
:RPS:PDB   71->158 2d7dA PDBj 3e-06 18.2 %
:RPS:PDB   289->394 1cu1A PDBj 5e-04 11.9 %
:RPS:PDB   544->1103 1cy7A PDBj 8e-95 28.9 %
:RPS:SCOP  64->279 1gkuB1  c.37.1.16 * 6e-20 36.0 %
:RPS:SCOP  288->499 1gkuB2  c.37.1.16 * 1e-09 25.2 %
:RPS:SCOP  544->1100 1gkuB3  e.10.1.1 * 5e-98 43.8 %
:HMM:SCOP  3->262 1gl9B1 c.37.1.16 * 2.4e-32 25.7 %
:HMM:SCOP  285->535 1gkuB2 c.37.1.16 * 3.8e-38 26.6 %
:HMM:SCOP  535->1101 1gkuB3 e.10.1.1 * 3.5e-134 34.4 %
:RPS:PFM   90->147 PF00270 * DEAD 2e-04 36.2 %
:RPS:PFM   617->661 PF01155 * HypA 1e-04 46.5 %
:RPS:PFM   714->1090 PF01131 * Topoisom_bac 5e-41 39.0 %
:HMM:PFM   715->1090 PF01131 * Topoisom_bac 2e-94 36.1 360/404  
:HMM:PFM   544->697 PF01751 * Toprim 1.7e-25 46.8 94/96  
:HMM:PFM   82->261 PF00270 * DEAD 7e-17 23.3 150/167  
:BLT:SWISS 1->1104 RGYR_THEMA 0.0 100.0 %
:PROS 778->786|PS00572|GLYCOSYL_HYDROL_F1_1
:COIL
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAD35266.1 GT:GENE AAD35266.1 GT:PRODUCT reverse gyrase GT:DATABASE GIB00025CH01 GT:ORG tmar0 GB:ACCESSION GIB00025CH01 GB:LOCATION 178967..182281 GB:FROM 178967 GB:TO 182281 GB:DIRECTION + GB:PRODUCT reverse gyrase GB:NOTE similar to PID:1698674 percent identity: 63.10; identified by sequence similarity; putative GB:PROTEIN_ID AAD35266.1 GB:DB_XREF GI:4980668 LENGTH 1104 SQ:AASEQ MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKLVELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG GT:EXON 1|1-1104:0| SW:ID RGYR_THEMA SW:DE RecName: Full=Reverse gyrase;Includes: RecName: Full=Helicase; EC=3.6.1.-;Includes: RecName: Full=Topoisomerase; EC=5.99.1.3; SW:GN Name=rgy; Synonyms=topR; OrderedLocusNames=TM_0173; SW:KW ATP-binding; Complete proteome; DNA-binding; Helicase; Hydrolase;Isomerase; Metal-binding; Nucleotide-binding; Topoisomerase; Zinc;Zinc-finger. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1104|RGYR_THEMA|0.0|100.0|1104/1104| GO:SWS:NREP 8 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0003677|"GO:DNA binding"|DNA-binding| GO:SWS GO:0004386|"GO:helicase activity"|Helicase| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0016853|"GO:isomerase activity"|Isomerase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0003916|"GO:DNA topoisomerase activity"|Topoisomerase| PROS 778->786|PS00572|GLYCOSYL_HYDROL_F1_1|PDOC00495| COIL:NAA 18 COIL:NSEG 1 COIL:REGION 513->530| SEG 159->172|kkeekekfeksfee| SEG 197->206|fdfvfvddvd| SEG 319->330|eeegkelyeylk| SEG 502->516|llliaeeeiieeaea| SEG 520->542|elvheveesrrrsereltdtsrs| SEG 778->791|llvlengvnleveg| SEG 987->996|kikekkfykk| BL:PDB:NREP 1 BL:PDB:REP 46->1100|1gl9C|e-166|40.0|985/1005| RP:PDB:NREP 3 RP:PDB:REP 71->158|2d7dA|3e-06|18.2|88/621| RP:PDB:REP 289->394|1cu1A|5e-04|11.9|101/645| RP:PDB:REP 544->1103|1cy7A|8e-95|28.9|509/563| RP:PFM:NREP 3 RP:PFM:REP 90->147|PF00270|2e-04|36.2|58/167|DEAD| RP:PFM:REP 617->661|PF01155|1e-04|46.5|43/113|HypA| RP:PFM:REP 714->1090|PF01131|5e-41|39.0|349/407|Topoisom_bac| HM:PFM:NREP 3 HM:PFM:REP 715->1090|PF01131|2e-94|36.1|360/404|Topoisom_bac| HM:PFM:REP 544->697|PF01751|1.7e-25|46.8|94/96|Toprim| HM:PFM:REP 82->261|PF00270|7e-17|23.3|150/167|DEAD| GO:PFM:NREP 9 GO:PFM GO:0003676|"GO:nucleic acid binding"|PF00270|IPR011545| GO:PFM GO:0005524|"GO:ATP binding"|PF00270|IPR011545| GO:PFM GO:0008026|"GO:ATP-dependent helicase activity"|PF00270|IPR011545| GO:PFM GO:0006464|"GO:protein modification process"|PF01155|IPR000688| GO:PFM GO:0016151|"GO:nickel ion binding"|PF01155|IPR000688| GO:PFM GO:0003677|"GO:DNA binding"|PF01131|IPR013497| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01131|IPR013497| GO:PFM GO:0005694|"GO:chromosome"|PF01131|IPR013497| GO:PFM GO:0006265|"GO:DNA topological change"|PF01131|IPR013497| RP:SCP:NREP 3 RP:SCP:REP 64->279|1gkuB1|6e-20|36.0|200/237|c.37.1.16| RP:SCP:REP 288->499|1gkuB2|1e-09|25.2|202/242|c.37.1.16| RP:SCP:REP 544->1100|1gkuB3|5e-98|43.8|520/532|e.10.1.1| HM:SCP:REP 3->262|1gl9B1|2.4e-32|25.7|222/249|c.37.1.16|1/1|P-loop containing nucleoside triphosphate hydrolases| HM:SCP:REP 285->535|1gkuB2|3.8e-38|26.6|241/248|c.37.1.16|2/2|P-loop containing nucleoside triphosphate hydrolases| HM:SCP:REP 535->1101|1gkuB3|3.5e-134|34.4|552/556|e.10.1.1|2/2|Prokaryotic type I DNA topoisomerase| OP:NHOMO 1034 OP:NHOMOORG 919 OP:PATTERN 332333322222222312121122---111---1-221111111--111-1113222222211-23-- 1111111111111111111-1111111111111111111111111111111111111111111111111111111111--1--3-222121111121--11111111211111111111111111111111111111111111111323211111111111111112222111111111111111112221111111111111111111111111111112-1221111111111111111111111111111211111111111111111111111111141121111111111111111111111121111111111111121111111111111113111111111211111111111111111122-11111111111111111111111111111111111111-111111121111111111111111111111111111111111111111111111111111111111111111111111111111111111----------------------------------------------------1112111111111------1111-1111111111111111111111111111111111211111232121111221211111211111111111111111111111111-111111--11111111111111111111-1111111111111111111111111111111111111111111111111111-111111111111--1111111111111111111111211111111211211111111122112111111111111111111111111111111111111111111111211111111111111111111111111111-111-1111111111111112112121222--- ---1-1------------------------------------------------------------------------------------------1-----------1--1---1------------------------1-------------1-111-----------2----11128111111112-121-1---- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------1---- STR:NPRED 1065 STR:RPRED 96.5 SQ:SECSTR #################################THHHHTTccHHHHHTHHHcHHHHHHHTTccGGGcHHHccccccccccTTHHHHHHHHHHHHHTTccEEEEEEcTTccHHHHHHHHHHcccEEEEcccHHHHHHHHHHHHHHcTcEEEEEcccEEEccHHcHHHHHHHHHccEEEEEHHHHHHHHHHHHTcccGGEEEcccH##HHHGcccccccEEEEETHHHHHTTcccccEEccEEccTTTGGGcccEEEEEEccccTTccHHcccEEEEcccccccccEEcccEEEccHHHHHHHHHHHHHHHHHEEEEcccHHHHHHHHHHHHHTcccccEEccHHHHHTTTTccccEEEEcTccTTccccTTccTHHHHTTcccccEccccccEEEccccGGGTcccccGGGHHHHHccccTTTcHHHHHHH#cccccccccccccccccccccc##cEEEEcHHHHHHHHHTTccEETTEEccccEEEEcccHHHHHHHHHHHHTTcccccccccccTHHHHHHHHHHHHHHHTGGGccccEEEEEEEccHHHHHHHHTTccTTEEEcccTEEEEEEETTTEEEEEEEcccccEEccccHHHHHHTccHHHHHHHTEEEEccHHHTEEEETTTTTEEccccEEcTTTHHHHHHHHHHHHTccEEEEcccccHHHHHHHHHHHHHHcccGGGEEEcccccccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHTcTcTccccTTHHHHHHHHHHHHHHHHHEETTEEcccccHHHHHHHHHHHTTccEEEccccEEEEEEcccccccHHHHHHHHHHHHcccHHHHHHHHHHHHHTTcccccccccccccHHHHHHHHHHHHHHTcGGGcccccccccccccccccccTTccHHHHTTccGGGcccccHHHHHHHHHHHHHHHHHTcccEEEEEEEEEEEETTEEEEEEEEEEEEEcGGGGGccccccccccTTcEEEEEEEEEEEEEcccccHHHHHHHHHHTTcccTTTHHHHHHHTTTTTcEEEETcTEEEEcHHHHHHHHHHHHHcHHHHcHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHH# DISOP:02AL 1-2, 164-165, 523-543, 880-887, 991-996| PSIPRED cccccccccccccccccccHHHHHccccccccccccccHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHccccEEEEcccccHHHHHHHHHHHHHHHcccEEEEEEccHHHHHHHHHHHHHHHccccEEEEEEccccHHHHHHHHHHHHccccEEEEEccHHHHHHHHHcccccEEEEEEEcHHHHHHccccHHHHHHHHcccHHHHHHHHHccccHHHHHHHHHccccEEEEEEcccccHHHHHHHHHHHHccccccHHHEEEEEEEEEEcccHHHHHHHHHHHHcccEEEEEEcHHHHHHHHHHHHHccccEEEcHHHHHHHHHHHHccccEEEEEEcccccEEEEccccccccEEEEEccccccccccHHccccHHHEEEcccccEEEcccHHHHHHHHHHHHHHHccHHHHHHHHHHccHHHHHcccccEEEccHHHHHHHccccccccccccccccEEEEEEccHHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHcccccccccccEEEEEEEccHHHHHHHHHcccccEEcccccEEccEEEccccEEEEEEEccHHccccccccccccccccccccccccccccccccccccHHHHHcccccccccccHHHHHHHHHHHHHHccEEEEEcccccHHHHHHHHHHHHHccccccEEEEEEEcccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHccHHHHHHHcccccEEccccHHHHHHHHHHHHHHHcccccEEEEEEcccccHHHHHHHccccEEEEEEEccEEEEcccccccHHHHHHHHHHHHcccHHHHHHHHHHHHHcccEEccccccccccHHHHHHHHHHHHHHccccccccccccccccccccccccccccHHHHHHccccHHHcccHHHHHHHHHHHHHHHHHHcHHHEEEEEEEEEEEccEEEEEEEEEEEEEccHHHcccccccccccccEEEEEcEEEccccccccccHHHHHHHHHHcccccccccHHHHHHHHccccEEEccccEEEEcHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHcc //