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Thermotoga maritima MSB8 (tmar0)
Gene : AAD35575.1
DDBJ      :             regulatory protein, SIR2 family
Swiss-Prot:NPD_THEMA    RecName: Full=NAD-dependent deacetylase;         EC=3.5.1.-;AltName: Full=Regulatory protein SIR2 homolog;

Homologs  Archaea  35/68 : Bacteria  556/915 : Eukaryota  193/199 : Viruses  2/175   --->[See Alignment]
c.31.1
:246 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->244 2h2iA PDBj e-140 100.0 %
:RPS:PDB   1->246 3d81A PDBj 4e-34 97.4 %
:RPS:SCOP  4->242 1iciA  c.31.1.5 * 1e-75 39.4 %
:HMM:SCOP  1->245 1yc5A1 c.31.1.5 * 2.4e-85 45.9 %
:RPS:PFM   21->195 PF02146 * SIR2 2e-39 49.4 %
:HMM:PFM   21->195 PF02146 * SIR2 6.3e-57 46.2 173/181  
:BLT:SWISS 1->246 NPD_THEMA e-140 100.0 %

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAD35575.1 GT:GENE AAD35575.1 GT:PRODUCT regulatory protein, SIR2 family GT:DATABASE GIB00025CH01 GT:ORG tmar0 GB:ACCESSION GIB00025CH01 GB:LOCATION complement(519723..520463) GB:FROM 519723 GB:TO 520463 GB:DIRECTION - GB:PRODUCT regulatory protein, SIR2 family GB:NOTE similar to GB:AE000782 percent identity: 64.20; identified by sequence similarity; putative GB:PROTEIN_ID AAD35575.1 GB:DB_XREF GI:4981001 LENGTH 246 SQ:AASEQ MKMKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVMEEGGIS GT:EXON 1|1-246:0| SW:ID NPD_THEMA SW:DE RecName: Full=NAD-dependent deacetylase; EC=3.5.1.-;AltName: Full=Regulatory protein SIR2 homolog; SW:GN Name=npdA; OrderedLocusNames=TM_0490; SW:KW 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Metal-binding;NAD; Zinc. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->246|NPD_THEMA|e-140|100.0|246/246| GO:SWS:NREP 3 GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| BL:PDB:NREP 1 BL:PDB:REP 1->244|2h2iA|e-140|100.0|244/244| RP:PDB:NREP 1 RP:PDB:REP 1->246|3d81A|4e-34|97.4|235/235| RP:PFM:NREP 1 RP:PFM:REP 21->195|PF02146|2e-39|49.4|172/178|SIR2| HM:PFM:NREP 1 HM:PFM:REP 21->195|PF02146|6.3e-57|46.2|173/181|SIR2| GO:PFM:NREP 6 GO:PFM GO:0006342|"GO:chromatin silencing"|PF02146|IPR003000| GO:PFM GO:0006476|"GO:protein amino acid deacetylation"|PF02146|IPR003000| GO:PFM GO:0008270|"GO:zinc ion binding"|PF02146|IPR003000| GO:PFM GO:0016811|"GO:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"|PF02146|IPR003000| GO:PFM GO:0045449|"GO:regulation of transcription"|PF02146|IPR003000| GO:PFM GO:0070403|"GO:NAD binding"|PF02146|IPR003000| RP:SCP:NREP 1 RP:SCP:REP 4->242|1iciA|1e-75|39.4|236/256|c.31.1.5| HM:SCP:REP 1->245|1yc5A1|2.4e-85|45.9|242/0|c.31.1.5|1/1|DHS-like NAD/FAD-binding domain| OP:NHOMO 1728 OP:NHOMOORG 786 OP:PATTERN 11---11111111111-12222221--1---11----------------1---11111111---1--1 1-1-22-222211112211-12112211111222222111-1111122-111111121--1221221121111111111-1111-11111111111---11111111111---------------1----1---1-11133---511------------------------------------11111---111111111111111111111111111222-1--111111111111111111111111111111111111111111132-1-111----------1--------------------------1----------1-1111111111111111111-11111111-1---111-11-112-111111-111-----11222---11111--------------1--111--1-------------1111---11111111---------11--111------------------------------1111-11-112111122111-11121111-11312222--1111-12222--1---2----11----------111122111---11----11-11111211212322-1--11111-2111111111--221--11-121-11-11111111111111111111--1-21-------111111111111111-1-1111111111111111111111111111111111111111111111111111-111111111111-------------1122----11--1-11---11111111-113-2222121211--22432----------111111111111111111111111-------1111111--------1-1----------1--------------1111111111-1- 22--544-93343454553466665664444433443444444344235434662464455444454333455554444445554423-444537444342-354315IGECA87953143475EA3B3KsA-C8E4655A5676274536417657685467C754744765A83224R1213252234546643343 -------------------1--------------------------------------------------------------------------------------------------------------------------------------------1-------------- STR:NPRED 246 STR:RPRED 100.0 SQ:SECSTR cccHHHHHHHHHcccEEEEEcGGGTGGGTccccccTTcHHHGTcHHTTcHHHHHHcHHHHHHHHHHHTGGGGGccccHHHHHHHHHHHTTcccEEEEcccccHHHHHTcccEEETTEEEEEEEETTTccEEEHHHHHHHGGGccccccTTTcccEEEEEcccTccccHHHHHHHHHHHHHccEEEEEccccccTTGGGHHHHHHHTTcEEEEEcccccTTTTTccEEEcccHHHHHHHHHHHHTcc DISOP:02AL 246-247| PSIPRED ccHHHHHHHHHHcccEEEEEcccccHHcccccccccccccccccHHHccHHHHHHcHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHccccEEEEEcccccHHHHcccccEEEEEEEEEEEEEccccccccHHHHHHHHccccccccccccccccccEEEccccccHHHHHHHHHHHHHccEEEEEccccEEccHHHHHHHHHHccccEEEEccccccccccEEEEEcccHHHHHHHHHHHHccc //