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Thermotoga maritima MSB8 (tmar0)
Gene : AAD36830.1
DDBJ      :             formate--tetrahydrofolate ligase
Swiss-Prot:FTHS_THEMA   RecName: Full=Formate--tetrahydrofolate ligase;         EC=6.3.4.3;AltName: Full=Formyltetrahydrofolate synthetase;         Short=FHS;         Short=FTHFS;

Homologs  Archaea  7/68 : Bacteria  350/915 : Eukaryota  187/199 : Viruses  0/175   --->[See Alignment]
c.37.1
:542 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   2->542 3do6A PDBj 0.0 99.6 %
:RPS:PDB   1->540 1eg7A PDBj 1e-73 50.0 %
:RPS:SCOP  1->540 1eg7A  c.37.1.10 * 1e-63 49.7 %
:HMM:SCOP  1->540 1eg7A_ c.37.1.10 * 1.6e-235 60.2 %
:RPS:PFM   1->541 PF01268 * FTHFS 0.0 57.7 %
:HMM:PFM   1->541 PF01268 * FTHFS 3.9e-251 58.6 541/555  
:BLT:SWISS 1->542 FTHS_THEMA 0.0 100.0 %
:PROS 91->101|PS00721|FTHFS_1
:PROS 316->327|PS00722|FTHFS_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAD36830.1 GT:GENE AAD36830.1 GT:PRODUCT formate--tetrahydrofolate ligase GT:DATABASE GIB00025CH01 GT:ORG tmar0 GB:ACCESSION GIB00025CH01 GB:LOCATION 1742057..1743685 GB:FROM 1742057 GB:TO 1743685 GB:DIRECTION + GB:PRODUCT formate--tetrahydrofolate ligase GB:NOTE similar to SP:P13419 PID:144810 percent identity: 74.14; identified by sequence similarity; putative GB:PROTEIN_ID AAD36830.1 GB:DB_XREF GI:4982345 LENGTH 542 SQ:AASEQ MKPIKEIADQLELKDDILYPYGHYIAKIDHRFLKSLENHEDGKLILVTAVTPTPAGEGKTTTSIGLSMSLNRIGKKSIVTLREPSLGPTLGLKGGATGGGRSRVLPSDEINLHFTGDMHAVASAHNLLAAVLDSHIKHGNELKIDITRVFWKRTMDMNDRALRSIVIGLGGSANGFPREDSFIITAASEVMAILALSENMKDLKERLGKIIVALDADRKIVRISDLGIQGAMAVLLKDAINPNLVQTTEGTPALIHCGPFANIAHGTNSIIATKMAMKLSEYTVTEAGFGADLGAEKFIDFVSRVGGFYPNAAVLVATVRALKYHGGANLKNIHEENLEALKEGFKNLRVHVENLRKFNLPVVVALNRFSTDTEKEIAYVVKECEKLGVRVAVSEVFKKGSEGGVELAKAVAEAAKDVEPAYLYEMNDPVEKKIEILAKEIYRAGRVEFSDTAKNALKFIKKHGFDELPVIVAKTPKSISHDPSLRGAPEGYTFVVSDLFVSAGAGFVVALSGDINLMPGLPKKPNALNMDVDDSGNIVGVS GT:EXON 1|1-542:0| SW:ID FTHS_THEMA SW:DE RecName: Full=Formate--tetrahydrofolate ligase; EC=6.3.4.3;AltName: Full=Formyltetrahydrofolate synthetase; Short=FHS; Short=FTHFS; SW:GN Name=fhs; OrderedLocusNames=TM_1766; SW:KW 3D-structure; ATP-binding; Complete proteome; Ligase;Nucleotide-binding; One-carbon metabolism. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->542|FTHS_THEMA|0.0|100.0|542/542| GO:SWS:NREP 4 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006730|"GO:one-carbon metabolic process"|One-carbon metabolism| PROS 91->101|PS00721|FTHFS_1|PDOC00595| PROS 316->327|PS00722|FTHFS_2|PDOC00595| SEG 86->100|lgptlglkggatggg| SEG 405->421|velakavaeaakdvepa| BL:PDB:NREP 1 BL:PDB:REP 2->542|3do6A|0.0|99.6|529/530| RP:PDB:NREP 1 RP:PDB:REP 1->540|1eg7A|1e-73|50.0|540/549| RP:PFM:NREP 1 RP:PFM:REP 1->541|PF01268|0.0|57.7|541/553|FTHFS| HM:PFM:NREP 1 HM:PFM:REP 1->541|PF01268|3.9e-251|58.6|541/555|FTHFS| GO:PFM:NREP 3 GO:PFM GO:0004329|"GO:formate-tetrahydrofolate ligase activity"|PF01268|IPR000559| GO:PFM GO:0005524|"GO:ATP binding"|PF01268|IPR000559| GO:PFM GO:0009396|"GO:folic acid and derivative biosynthetic process"|PF01268|IPR000559| RP:SCP:NREP 1 RP:SCP:REP 1->540|1eg7A|1e-63|49.7|539/549|c.37.1.10| HM:SCP:REP 1->540|1eg7A_|1.6e-235|60.2|538/0|c.37.1.10|1/1|P-loop containing nucleoside triphosphate hydrolases| OP:NHOMO 758 OP:NHOMOORG 544 OP:PATTERN ------------------------1---1-1--------------1---------------111---- 1----11----111--------------------------------11----111--1----11--1----111111111123-----1111-111----1-----------------------------------1111111211----------------------------------------1-111-1-111111111111111--111-111---2-111111111-1111111111111111111212111111121111111111111111111211121111111111111222222222222221111111111211111111111111111111111111111122211111111111111111------1--111-----------------------1111111111--1--11111111111-111121111112--------1---1--------------------------------1----1---------------------------------------1-------------1-1-11111111-------1111-1-1-----1-------------1-11-11------------------------11---------11111--111111111111-----------------1---------------------------------------1--------------------------1------------------------1----111---1-----------------1-----------------------------11111111111121-----------------1--------------1-1------------------1---1111111111111111 ----111-21--1111111111111111111111111111-111111111111111111111222222122121222-3222222122-12111111111111212-12223334342222222552835R6-5232222322322222222242223313311143411332111111H1111111521211112113 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 542 STR:RPRED 100.0 SQ:SECSTR cccHHHHHHTTTccGGGEEEcccccEEEcTHHHHHHTTccccEEEEEEEccccTTcccHHHHHHHHHHHHHHTTccEEEEEcccccTHHHHTTccccEETTEEEEcHHHHHTTTTcHHHHHHHHHHHHHHHHHHHHHTTcTTcccGGGccccEEEccccGGGccEEEccccTTccccEEEcEEEGGGcHHHHHHHHcccHHHHHHHHHTcEEEEcTTccEEETGGGTcHHHHHHHTTTTTccEEEEETTccEEEEccccccccccccccHHHHHHHHHHccEEEEEccccTTTHHHHHHHTHHHHHTccccEEEEEEcHHHHHHTTTccGGGTTcccHHHHHHHHHHHHHHHHHHHTTTccEEEEEEccTTccHHHHHHHHHHTTTcEEEEEccTTTGGGGGHHHHHHHHHHHHHccccccccccTTccHHHHHHHHHHHTTcccEEEEcHHHHHHHHHHHHTTcTTccEEEEccTTcccccTTccccccccEEEEcccEEETTTEEEEEcccTTccccccccccGGGTcEEccccEEcccc PSIPRED cccHHHHHHHccccHHHcccccccEEEEcHHHHHHHccccccEEEEEEEccccccccccHHHHHHHHHHHHHcccEEEEEEccccccccccccccccccccEEEEcHHHccccccccHHHHHHHHHHHHHHHHHHHHccccccccccEEEEEEEcccccHHHHEEEEcccccccccEEccccEEcHHHHHHHHHHHHccHHHHHHHHHcEEEEEEcccccEEEEEcccHHHHHHHHHHHccccEEEEEcccEEEEEccccHHHHccccHHHHHHHHHHHccEEEEEccccccccccEEEEEEcccccccccEEEEEEccHHHHHcccccHHHHccccHHHHHHHHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHHccccEEEEHHHHHccHHHHHHHHHHHHHHHcccccccccccccHHHHHHHHHHHHcccccEEEcHHHHHHHHHHHHcccccccEEEEEccccccccHHHcccccccEEEEEEEEEEccccEEEEEEccccccccccccccHHccEEccccEEEccc //