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Thermotoga maritima MSB8 (tmar0)
Gene : AAD36889.1
DDBJ      :             GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Swiss-Prot:RIBBA_THEMA  RecName: Full=Riboflavin biosynthesis protein ribBA;Includes:  RecName: Full=3,4-dihydroxy-2-butanone 4-phosphate synthase;           Short=DHBP synthase;           EC=4.1.99.12;Includes:  RecName: Full=GTP cyclohydrolase-2;           EC=3.5.4.25;  AltName: Full=GTP cyclohydrolase II;

Homologs  Archaea  34/68 : Bacteria  782/915 : Eukaryota  122/199 : Viruses  0/175   --->[See Alignment]
c.144.1d.115.1
:388 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->161 1tksA PDBj 3e-21 39.0 %
:BLT:PDB   191->352 2bz0B PDBj 4e-42 53.7 %
:RPS:PDB   189->352 2bz0A PDBj 3e-22 50.9 %
:RPS:SCOP  1->180 1g57A  d.115.1.2 * 1e-46 28.8 %
:RPS:SCOP  189->352 2bz0A1  c.144.1.1 * 5e-55 52.8 %
:HMM:SCOP  1->188 1g57A_ d.115.1.2 * 4.4e-49 35.6 %
:HMM:SCOP  189->359 2bz1A1 c.144.1.1 * 2.1e-56 58.5 %
:RPS:PFM   1->180 PF00926 * DHBP_synthase 1e-26 39.4 %
:RPS:PFM   195->352 PF00925 * GTP_cyclohydro2 1e-52 60.8 %
:HMM:PFM   191->353 PF00925 * GTP_cyclohydro2 8.1e-68 57.7 163/169  
:HMM:PFM   1->182 PF00926 * DHBP_synthase 9e-50 39.0 182/194  
:BLT:SWISS 1->388 RIBBA_THEMA 0.0 100.0 %

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAD36889.1 GT:GENE AAD36889.1 GT:PRODUCT GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase GT:DATABASE GIB00025CH01 GT:ORG tmar0 GB:ACCESSION GIB00025CH01 GB:LOCATION complement(1801367..1802533) GB:FROM 1801367 GB:TO 1802533 GB:DIRECTION - GB:PRODUCT GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase GB:NOTE similar to GB:L09228 SP:P17620 GB:X51510 PID:40087 PID:410127 percent identity: 63.08; identified by sequence similarity; putative GB:PROTEIN_ID AAD36889.1 GB:DB_XREF GI:4982408 LENGTH 388 SQ:AASEQ MEELREAFEEGKPVILIDRNRENEADFVFPAQLITEDVVSFFVTYGKGLFCVTADEEDLLKRGFVKLSSNYGANYFVPVDWGTGTGISALERAETCRKLAEGRYFHEFRYPGHVTVIGGIGFQRRKGHTEASLEISELAGFSRHAVIVEILDEKGNSHNLDYVLKLSEKFSLPVLEMDDVWREFVKRKLLMKKKAEATLPTDFGVFKVVSFENHLDGKEHFAIVKEPLEDPVAVRIHSECVTGDVLSSLRCDCGSQLANFLRYMSAHGGILIYLRQEGRGIGLSNKIAAYSLQDKGLDTVEANRVLGFSEDERDYAPAAQILKALGIERVLLFTNNQRKTVGLEKYGIEVVETKRLYGRVTPHNRFYLSTKMKKLGHELEEIFREVNS GT:EXON 1|1-388:0| SW:ID RIBBA_THEMA SW:DE RecName: Full=Riboflavin biosynthesis protein ribBA;Includes: RecName: Full=3,4-dihydroxy-2-butanone 4-phosphate synthase; Short=DHBP synthase; EC=4.1.99.12;Includes: RecName: Full=GTP cyclohydrolase-2; EC=3.5.4.25; AltName: Full=GTP cyclohydrolase II; SW:GN Name=ribBA; OrderedLocusNames=TM_1826; SW:KW Complete proteome; GTP-binding; Hydrolase; Lyase; Magnesium;Manganese; Metal-binding; Multifunctional enzyme; Nucleotide-binding;Riboflavin biosynthesis; Zinc. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->388|RIBBA_THEMA|0.0|100.0|388/388| GO:SWS:NREP 7 GO:SWS GO:0005525|"GO:GTP binding"|GTP-binding| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0016829|"GO:lyase activity"|Lyase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0009231|"GO:riboflavin biosynthetic process"|Riboflavin biosynthesis| BL:PDB:NREP 2 BL:PDB:REP 1->161|1tksA|3e-21|39.0|159/196| BL:PDB:REP 191->352|2bz0B|4e-42|53.7|162/173| RP:PDB:NREP 1 RP:PDB:REP 189->352|2bz0A|3e-22|50.9|159/168| RP:PFM:NREP 2 RP:PFM:REP 1->180|PF00926|1e-26|39.4|180/194|DHBP_synthase| RP:PFM:REP 195->352|PF00925|1e-52|60.8|158/169|GTP_cyclohydro2| HM:PFM:NREP 2 HM:PFM:REP 191->353|PF00925|8.1e-68|57.7|163/169|GTP_cyclohydro2| HM:PFM:REP 1->182|PF00926|9e-50|39.0|182/194|DHBP_synthase| GO:PFM:NREP 4 GO:PFM GO:0008686|"GO:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"|PF00926|IPR000422| GO:PFM GO:0009231|"GO:riboflavin biosynthetic process"|PF00926|IPR000422| GO:PFM GO:0003935|"GO:GTP cyclohydrolase II activity"|PF00925|IPR000926| GO:PFM GO:0009231|"GO:riboflavin biosynthetic process"|PF00925|IPR000926| RP:SCP:NREP 2 RP:SCP:REP 1->180|1g57A|1e-46|28.8|177/205|d.115.1.2| RP:SCP:REP 189->352|2bz0A1|5e-55|52.8|159/168|c.144.1.1| HM:SCP:REP 1->188|1g57A_|4.4e-49|35.6|188/209|d.115.1.2|1/1|YrdC/RibB| HM:SCP:REP 189->359|2bz1A1|2.1e-56|58.5|171/0|c.144.1.1|1/1|RibA-like| OP:NHOMO 1623 OP:NHOMOORG 938 OP:PATTERN ---11--111111111--111111-----1--11-11---111--1--1------1-111-211---- 2221311111121111111-1111211111122111213411112-111111-322122222312234311----1-----12111111212-111---2121111112111111111111111111121111121222-111111111111211111111111111111111111111111111111---1111111121311112111111311111112211------1311111111111111111111--1----2---1111----111-111111-------11111111111-----------------------11-11222211311111111111-111--1111111211211111-1-11111-111111112111111111111-1111111111-11211211111112211212221122111223222222211111111211112232222222222---------------222212442222222344335344443332444424443433311222411221111112211213212222222111211122121221122221212311122332324113222222222222222222222222223342223123233333233333333333332-1111122-22222222222222222222-2222222222222222222222223322222222222222222222222222222222222232222221111111112133111132212222122233333332223222223333343332333111111111122243333354344222222222222221111111111----------1----------------1--------11-111-111111 ------1-----2222222222122222222222222222222221222222222222222222222222222222222222222222-23222222222242232-23-------------------------------------------------1----1-----------1222N2212212462322254331 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 352 STR:RPRED 90.7 SQ:SECSTR HHHHHHHHHTTccEEEEcccTTcccEEEEEGGGccHHHHHHHHHTcccccEEEEEHHHHHHTTcccccccccccccccEEETccccccHHHHHHHHHHHHcTccGGGEEEEEEEEEEEEcTGGTcccHHHHHHHHHHHTTccccEEEEEccTTTcccccHHHHHHHHHHHTccEEEHHHHHHHHHHccccEEEEEEEEEEETTEEEEEEEEEETTTccEEEEEEEccccccccEEEEEccHHHHTcccccccHHHHHHHHHHHHHHHTcEEEEEccTTTTTcHHHHHHHHHHHTTcccTTccHHHTTcccccccTHHHHHHHHHTTcccEEEEcccHHHHHHHHHTTccEEE#################################### DISOP:02AL 385-388| PSIPRED cHHHHHHHHcccEEEEEEccccccHHHHHHHHHccHHHHHHHHHHcccEEEEEccHHHHHHcccccccccccccEEEEEEccccccccHHHHHHHHHHHcccccHHHccccccccccccccccccccccHHHHHHHHHHccccEEEEEEEEccccccccHHHHHHHHHHccccEEEHHHHHHHHHccccEEEEEEEEEcccccccEEEEEEEccccccEEEEEEEccccccccEEEEccccHHHHHccccccccHHHHHHHHHHHHcccEEEEEcccccHHHHHHHHHHHHHHHccccccccHHHcccccHHHHHHHHHHHHHHccccEEEEEcccHHHHHHHHccccEEEEEEEEEccccHHHHHHHHHHHHHHHHHcHHHHHcccc //