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Thermus thermophilus HB27 (tthe0)
Gene : AAS80601.1
DDBJ      :             5-methyltetrahydrofolate-homocysteine methyltransferase
Swiss-Prot:             

Homologs  Archaea  19/68 : Bacteria  629/915 : Eukaryota  90/199 : Viruses  0/175   --->[See Alignment]
a.46.1c.1.21c.1.26c.23.6c.5.1d.173.1
:1184 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   42->604 1q7zA PDBj 2e-63 34.9 %
:BLT:PDB   665->1183 1k7yA PDBj 2e-63 32.9 %
:RPS:PDB   36->626 3bolB PDBj 8e-69 29.2 %
:RPS:PDB   649->1183 3bulA PDBj 2e-47 29.4 %
:RPS:SCOP  36->345 1q7mA2  c.1.26.1 * 7e-49 35.8 %
:RPS:SCOP  369->632 1f6yA  c.1.21.2 * 1e-42 31.1 %
:RPS:SCOP  655->743 1bmtA1  a.46.1.1 * 2e-29 44.9 %
:RPS:SCOP  770->831 1j6uA1  c.5.1.1 * 2e-04 19.4 %
:RPS:SCOP  887->1183 1k7yA3  d.173.1.1 * 9e-76 24.6 %
:HMM:SCOP  36->410 1umyA_ c.1.26.1 * 8.8e-118 50.3 %
:HMM:SCOP  367->637 1f6yA_ c.1.21.2 * 1.2e-79 45.2 %
:HMM:SCOP  655->744 1bmtA1 a.46.1.1 * 2.4e-27 47.8 %
:HMM:SCOP  742->876 1bmtA2 c.23.6.1 * 7.4e-37 39.3 %
:HMM:SCOP  886->1183 1mskA_ d.173.1.1 * 1.4e-83 40.1 %
:RPS:PFM   49->336 PF02574 * S-methyl_trans 2e-47 43.8 %
:RPS:PFM   390->575 PF00809 * Pterin_bind 5e-06 35.1 %
:RPS:PFM   665->743 PF02607 * B12-binding_2 6e-25 68.4 %
:RPS:PFM   751->848 PF02310 * B12-binding 2e-16 41.8 %
:RPS:PFM   1049->1182 PF02965 * Met_synt_B12 3e-24 39.6 %
:HMM:PFM   49->337 PF02574 * S-methyl_trans 1.5e-72 42.1 285/305  
:HMM:PFM   1048->1183 PF02965 * Met_synt_B12 1.4e-53 47.1 136/136  
:HMM:PFM   368->576 PF00809 * Pterin_bind 1.1e-39 30.7 192/210  
:HMM:PFM   662->743 PF02607 * B12-binding_2 1.9e-32 50.0 82/84  
:HMM:PFM   749->863 PF02310 * B12-binding 1.5e-22 36.8 114/121  
:BLT:SWISS 41->1183 METH_MYCLE 0.0 49.4 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS80601.1 GT:GENE AAS80601.1 GT:PRODUCT 5-methyltetrahydrofolate-homocysteine methyltransferase GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION 241635..245189 GB:FROM 241635 GB:TO 245189 GB:DIRECTION + GB:PRODUCT 5-methyltetrahydrofolate-homocysteine methyltransferase GB:PROTEIN_ID AAS80601.1 GB:DB_XREF GI:46196183 LENGTH 1184 SQ:AASEQ MEVHACSPGCRHHLGGAGWGDAPLVRLGYNKEARAKKFPYLKALLERPLVFDGAMGTELQKRDLTPEDYGGEAYFGCPEVLNRTRPEVVREIHLAYLEAGAEVIETNTFGALRHVLAEYGLEEAAEELAFLGARIAREAADPYGAFVAGALGPGTKLVSLGQISWDALYRAYKEAARGLLKGGVDLILLETAQDILQVRCAVLAVREAMAEVGREVPLQVQVTFEATGTMLVGTDEQAALAALESLPVDVVGMNCATGPDLMDSKVRYFAEHSTRFVSCLPNAGLPRNEGGRVVYDLTPEELAKWHLKFVAEYGVNAVGGCCGTGPEHIRKVAEAVKGLAPKPRPESFPPQVASLYQAVSLKQEASLFLVGERLNATGSKRFREMLFARDLEGILALAREQVEEGAHALDLSVAWTGRDELEDLRWLLPHLATALTVPVMVDSTSPEAMELALKYLPGRVLLNSANLEDGLERFDRVASLAKAHGAALVVLAIDEKGMAKTREEKVRVALRMYERLTEHHGLRPEDLLFDLLTFPITQGDEESRPLAKETLLAIEELRERLPGVGFVLGVSNVSFGLKPRARRVLNSVFLDEARKRGLTAAIVDAGKILPISQIPEEAYALALDLIYDRRKEGFDPLLAFMAYFEAHKEDPGKREDAFLALPLLERLKRRVVEGRKQGLEADLEEALKAGHKPLDLINGPLLAGMKEVGDLFGAGKMQLPFVLQAAEVMKRAVAYLEPHMEKKGEGKGTLVLATVKGDVHDIGKNLVDIILSNNGYRVVNLGIKVPIEEILKAVEAHKPHAVGMSGLLVKSTLVMKENLEYMRDRGYTLPVILGGAALTRSYVEELKAIYPNVYYAEDAFEGLRLMEELTGHAPPELTRKAPARPKREAPKVAPRARPVGEAPAVPRPPFFGVRVEEGLDLATIAHYVNKLALYRGQWGYSRKGLSREAWQALVEREAEPVFQRLLKEAMAEGWLEPKVLYGFFPVAREGEELLVFSPETGEVLERFRFPRQRGGGLSLVDYFRPRFAAPLGDEADWMPKEAFRAGARDVLGVQLVTMGEAPSRKAQALFASGAYQDYLFVHGFSVEMTEALAEYWHKRMRQMWGIAHKDATEIQKLFQQGYQGARYSFGYPACPDLADQAKLDRLMGFHRVGVHLTENFQLEPEHATSALVVHHPEARYFSVD GT:EXON 1|1-1184:0| BL:SWS:NREP 1 BL:SWS:REP 41->1183|METH_MYCLE|0.0|49.4|1127/1206| SEG 116->133|laeygleeaaeelaflga| BL:PDB:NREP 2 BL:PDB:REP 42->604|1q7zA|2e-63|34.9|527/559| BL:PDB:REP 665->1183|1k7yA|2e-63|32.9|504/577| RP:PDB:NREP 2 RP:PDB:REP 36->626|3bolB|8e-69|29.2|545/549| RP:PDB:REP 649->1183|3bulA|2e-47|29.4|517/577| RP:PFM:NREP 5 RP:PFM:REP 49->336|PF02574|2e-47|43.8|281/296|S-methyl_trans| RP:PFM:REP 390->575|PF00809|5e-06|35.1|174/208|Pterin_bind| RP:PFM:REP 665->743|PF02607|6e-25|68.4|79/84|B12-binding_2| RP:PFM:REP 751->848|PF02310|2e-16|41.8|98/117|B12-binding| RP:PFM:REP 1049->1182|PF02965|3e-24|39.6|134/137|Met_synt_B12| HM:PFM:NREP 5 HM:PFM:REP 49->337|PF02574|1.5e-72|42.1|285/305|S-methyl_trans| HM:PFM:REP 1048->1183|PF02965|1.4e-53|47.1|136/136|Met_synt_B12| HM:PFM:REP 368->576|PF00809|1.1e-39|30.7|192/210|Pterin_bind| HM:PFM:REP 662->743|PF02607|1.9e-32|50.0|82/84|B12-binding_2| HM:PFM:REP 749->863|PF02310|1.5e-22|36.8|114/121|B12-binding| GO:PFM:NREP 11 GO:PFM GO:0008898|"GO:homocysteine S-methyltransferase activity"|PF02574|IPR003726| GO:PFM GO:0042558|"GO:pteridine and derivative metabolic process"|PF00809|IPR000489| GO:PFM GO:0008705|"GO:methionine synthase activity"|PF02607|IPR003759| GO:PFM GO:0009086|"GO:methionine biosynthetic process"|PF02607|IPR003759| GO:PFM GO:0031419|"GO:cobalamin binding"|PF02607|IPR003759| GO:PFM GO:0046872|"GO:metal ion binding"|PF02607|IPR003759| GO:PFM GO:0031419|"GO:cobalamin binding"|PF02310|IPR006158| GO:PFM GO:0046872|"GO:metal ion binding"|PF02310|IPR006158| GO:PFM GO:0005622|"GO:intracellular"|PF02965|IPR004223| GO:PFM GO:0008705|"GO:methionine synthase activity"|PF02965|IPR004223| GO:PFM GO:0009086|"GO:methionine biosynthetic process"|PF02965|IPR004223| RP:SCP:NREP 5 RP:SCP:REP 36->345|1q7mA2|7e-49|35.8|293/300|c.1.26.1| RP:SCP:REP 369->632|1f6yA|1e-42|31.1|251/258|c.1.21.2| RP:SCP:REP 655->743|1bmtA1|2e-29|44.9|89/90|a.46.1.1| RP:SCP:REP 770->831|1j6uA1|2e-04|19.4|62/89|c.5.1.1| RP:SCP:REP 887->1183|1k7yA3|9e-76|24.6|285/327|d.173.1.1| HM:SCP:REP 36->410|1umyA_|8.8e-118|50.3|358/0|c.1.26.1|1/1|Homocysteine S-methyltransferase| HM:SCP:REP 367->637|1f6yA_|1.2e-79|45.2|261/0|c.1.21.2|1/1|Dihydropteroate synthetase-like| HM:SCP:REP 655->744|1bmtA1|2.4e-27|47.8|90/90|a.46.1.1|1/1|Methionine synthase domain| HM:SCP:REP 742->876|1bmtA2|7.4e-37|39.3|135/156|c.23.6.1|1/1|Cobalamin (vitamin B12)-binding domain| HM:SCP:REP 886->1183|1mskA_|1.4e-83|40.1|277/327|d.173.1.1|1/1|Methionine synthase activation domain-like| OP:NHOMO 1191 OP:NHOMOORG 738 OP:PATTERN ----1-----------2------2--------14---12111-11----8EAB-----------1-23 23511-11111-1-11111-111111111111111111111111----1----11-----211-1111111----------31--11-443311-----2-2-21221-1---------------1111111111111111---3111111111111111111111111121111111111111111122-1212222222222222222222212222222---11111122-1111111111111111111-------1---22-------------111-----11----------------------------------47133222222212143331111112-112122Pc3212211D11141112112222-----111111111111111111111111121111111142-41111141114411222332555555311111111111111-1------------------------------22222111112222222-222222222222222222222222222222222222111111111-------111111-6A62121111111-232122222111113211-------------------11-11--1112111-1211111111111111111111---1111------111111-1111111111-111111111111111111111111--1111111111111111111111111--111111111111---1---------11111----11---------11111-111111111111111211111111--------1111111111111112222222222-----112111111------------------------------------1-11111111141 ----111-21----1------------------------------------------------------------------111-1-----------------121-131711111-1111111221213A1-124111111111112112112121121171651------132-111H1113-1--1---1121212 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 1132 STR:RPRED 95.6 SQ:SECSTR ###################################cHHHHHHHHHHccEEcccccHHHHGGGTcc###TT###ccccGGGHHHHcHHHHHHHHHHHHHHTccEEEcccTTccHHHHGGGTcGGGHHHHHHHHHHHHHHHHTTTTcEEEEEEccccccTTTccccHHHHHHHHHHHHHHHHHHTcccEEEEEEccHHHHHHHHHHHHHHccHHcccccEEEEEcccTTcccTTcccHHHHHHHHHTccccEEEEEccccHHHHHHHHHHHHTTcccEEEEEccccccEEETccccccccHHHHHTTHHHHHHTTTccEEcccTTccHHHHHHHHHHHccccccccccccccEEEcEEccccEEEccccEEEEEEEccTTcHHHHHHHHTTccHHHHHHHHHHHHTTccEEEEEcccGGGccHHHHHHHHHHHHHHTcccEEEEcccHHHHHHHHHHcccccEEEEEEccHTHHHHHHHHHHHHHHccEEEEEccccccccccHHHHHHHHHHHHHHHHHTTcccTTcEEEEcccccGGGTccHHHHGTccHHHHHHHHHHHHTTccccccGGGTTcTcTcccHHHHHHHHHHHHHHTTccEEEEcTTcHHHHHHHHHHHHHTTccccTTccccccccccccHHHHHHHHccGGGGccHHHHHHHHHHHHHHHHHTccTTHHHHHHHHHHHcccTTHHHHTHHHHHHHHHHHHHHHTcccHHHHHHHHHHHHHHHHHHHHHHHTccccccEEEEEEcTTccccHHHHHHHHHHHTTTcEEEEccccccHHHHHHHHHHHTccEEEEEcccTHHHHHHHHHHHHHHHTTccccEEEEcTTccHHHHHHHTGGGcEEEcccHHHHHHHHHHHTcTTTHHHHHHHHHHHHHHHHHHTTccTTcccccGGGcccccccccEEEEEEccHHHHTTcccHHHHHHTTccccTTGGcTTTHHHHHHHHHHHHHHHHHHHHHTccccEEEEEEEEEEEETTEEEEEccTTccEEEEEEcccccccccccccccGGGGcccGGG##########GGTccEEEEEEEEEccTTHHHHHHHHHHTTcHHHHHHHHHHHHHHHHHHHHHHHHHHHHTccccTTccccHHHHHTTccccccccTTcTTcccGGGHHHHHHHHTHHHHccEEcTTccEEcccEEEEEEcccTTcccccc# DISOP:02AL 1-3, 644-660, 742-745, 880-896| PSIPRED cEEccccccccccccccccccccccccccccccccccHHHHHHHHHccEEEEcHHHHHHHHcccccccccccccccccHHHccccHHHHHHHHHHHHHHHHHHHHcccccccHHHHHHccHHHHHHHHHHHHHHHHHHHHccccEEEEEEccccccccccccccHHHHHHHHHHHHHHHHcccccEEEEcccccHHHHHHHHHHHHHHHHHHccccEEEEEEEEcccccccccccHHHHHHHHHHcccEEEEEcccccHHHHHHHHHHHHHHccccEEEEccccccccccccEEccccHHHHHHHHHHHHHHcccEEEEEcccccHHHHHHHHHHHHcccccccccccccccccccccccccccccEEEEccEEcccccHHHHHHHHHccHHHHHHHHHHHHHccccEEEccccccccccHHHHHHHHHHHHHHHcccEEEEcccHHHHHHHHHHcccccEEEEcccccccHHHHHHHHHHHHccccEEEEccccccccccHHHHHHHHHHHHHHHHHHccccHHHEEEcccccccccccHHHHHHHHHHHHHHHHHHHHcccccEEEEEEcccccccHHHHHHHHHHHHHHHHHHHHHEEEccHHHHHHHccccHHHHHHHHHHHHccccccHHHHHHHHHHHHcccccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHccccccccEEEEEEEcccHHHHHHHHHHHHHHHcccEEEEccccccHHHHHHHHHHccccEEEEcccHHccHHHHHHHHHHHHHcccccEEEEEcccccHHHHHHHHHccccEEEEccHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHccccccccccccccccccccEEEEcccHHHHHHHHcccHHHHHccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHcccccEEEEEEEEEccccccEEEEEEccccEEEEEEcccHHcccccccccccccccccccccHHccccccHHcccccccccEEEEEEcHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccHHHHHHHHcccccccccccccccccHHHHHHHHHHcccccccEEEcHHHHccccHHHcEEEEEccccEEcccc //