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Thermus thermophilus HB27 (tthe0)
Gene : AAS81038.1
DDBJ      :             DNA polymerase I
Swiss-Prot:DPO1T_THET8  RecName: Full=DNA polymerase I, thermostable;         EC=2.7.7.7;AltName: Full=Tth polymerase 1;

Homologs  Archaea  0/68 : Bacteria  907/915 : Eukaryota  96/199 : Viruses  20/175   --->[See Alignment]
a.60.7c.120.1c.55.3e.8.1
:834 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   11->833 1cmwA PDBj 0.0 82.8 %
:RPS:PDB   1->833 1bgxT PDBj 0.0 81.6 %
:RPS:SCOP  10->174 1bgxT2  c.120.1.2 * 7e-10 84.6 %
:RPS:SCOP  175->288 1bgxT1  a.60.7.1 * 5e-30 74.3 %
:RPS:SCOP  308->417 1bgxT3  c.55.3.5 * 5e-48 80.0 %
:RPS:SCOP  432->833 1bgxT4  e.8.1.1 * e-152 87.9 %
:HMM:SCOP  1->174 1bgxT2 c.120.1.2 * 1.4e-59 50.3 %
:HMM:SCOP  175->291 1bgxT1 a.60.7.1 * 1e-35 51.7 %
:HMM:SCOP  295->424 1qtmA1 c.55.3.5 * 1.1e-35 35.4 %
:HMM:SCOP  425->833 1qtmA2 e.8.1.1 * 8e-155 56.7 %
:RPS:PFM   13->173 PF02739 * 5_3_exonuc_N 3e-39 52.2 %
:RPS:PFM   177->264 PF01367 * 5_3_exonuc 1e-21 48.9 %
:RPS:PFM   308->417 PF09281 * Taq-exonuc 4e-39 84.5 %
:RPS:PFM   480->829 PF00476 * DNA_pol_A e-113 58.7 %
:HMM:PFM   454->832 PF00476 * DNA_pol_A 2.6e-150 52.5 379/383  
:HMM:PFM   13->173 PF02739 * 5_3_exonuc_N 2.1e-62 61.5 161/169  
:HMM:PFM   294->422 PF09281 * Taq-exonuc 9.5e-60 61.2 129/138  
:HMM:PFM   175->262 PF01367 * 5_3_exonuc 2.4e-33 58.0 88/101  
:BLT:SWISS 1->834 DPO1T_THET8 0.0 98.6 %
:PROS 661->680|PS00447|DNA_POLYMERASE_A
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS81038.1 GT:GENE AAS81038.1 GT:PRODUCT DNA polymerase I GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION 671122..673626 GB:FROM 671122 GB:TO 673626 GB:DIRECTION + GB:PRODUCT DNA polymerase I GB:PROTEIN_ID AAS81038.1 GB:DB_XREF GI:46196622 LENGTH 834 SQ:AASEQ MEAMLPLFESKGRVLLVDGHHLAYRTFFALKGLTTSRGEPVQAVYGFAKSLLKALKEDGYKSVFVVFDAKAPSFRHEAYEAYKAGRAPTPEDFPRQLALIKELVDLLGFTRLEVPGYEADDVLATLAKKAEKEGYEVRILTADRDLYQLVSDRVAVLHPEGHLITPEWLWEKYGLRPEQWVDFRALVGDPSDNLPGVKGIGEKTALKLLKEWGSLESLLKNLDRVKPENVREKIKAHLEDLRLSLELSRVRADLPLEVDLAQGREPDREGLRAFLERLEFGSLLHEFGLLEAPTPLEEAPWPPPEGAFVGFVLSRPEPMWAELKALAACRDGRVHRAEDPLAGLGDLEEVRGLLAKDLAVLALREGLDLAPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEDAAHRALLSERLHRNLLKRLEGEEKLLWLYHEVEKPLSRVLAHMEATGVRLDVAYLQALSLELAEEIRRLEEEVFRLAGHPFNLNSRDQLERVLFDELRLPALGKTQKTGKRSTSAAVLEALREAHPIVEKILQHRELTKLKNTYVDPLPSLVHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFVAEAGWALVALDYSQIELRVLAHLSGDENLIRVFQEGKDIHTQTASWMFGVPPEAVDPLMRRAAKTVNFGVLYGMSAHRLSQELAIPYEEAVAFIERYFQSFPKVRAWIEKTLEEGRKRGYVETLFGRRRYVPDLNARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLREMGARMLLQVHDELLLEAPQARAEEVAALAKEAMEKAYPLAVPLEVEVGIGEDWLSAKG GT:EXON 1|1-834:0| SW:ID DPO1T_THET8 SW:DE RecName: Full=DNA polymerase I, thermostable; EC=2.7.7.7;AltName: Full=Tth polymerase 1; SW:GN Name=polA; OrderedLocusNames=TTHA1054; SW:KW Complete proteome; DNA damage; DNA repair; DNA replication;DNA-binding; DNA-directed DNA polymerase; Nucleotidyltransferase;Transferase. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->834|DPO1T_THET8|0.0|98.6|834/834| GO:SWS:NREP 7 GO:SWS GO:0006974|"GO:response to DNA damage stimulus"|DNA damage| GO:SWS GO:0006281|"GO:DNA repair"|DNA repair| GO:SWS GO:0006260|"GO:DNA replication"|DNA replication| GO:SWS GO:0003677|"GO:DNA binding"|DNA-binding| GO:SWS GO:0003887|"GO:DNA-directed DNA polymerase activity"|DNA-directed DNA polymerase| GO:SWS GO:0016779|"GO:nucleotidyltransferase activity"|Nucleotidyltransferase| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 661->680|PS00447|DNA_POLYMERASE_A|PDOC00412| SEG 238->249|ledlrlslelsr| SEG 289->307|lleaptpleeapwpppega| SEG 418->431|llkrlegeekllwl| SEG 461->479|lslelaeeirrleeevfrl| BL:PDB:NREP 1 BL:PDB:REP 11->833|1cmwA|0.0|82.8|815/817| RP:PDB:NREP 1 RP:PDB:REP 1->833|1bgxT|0.0|81.6|827/828| RP:PFM:NREP 4 RP:PFM:REP 13->173|PF02739|3e-39|52.2|161/165|5_3_exonuc_N| RP:PFM:REP 177->264|PF01367|1e-21|48.9|88/100|5_3_exonuc| RP:PFM:REP 308->417|PF09281|4e-39|84.5|110/131|Taq-exonuc| RP:PFM:REP 480->829|PF00476|e-113|58.7|346/360|DNA_pol_A| HM:PFM:NREP 4 HM:PFM:REP 454->832|PF00476|2.6e-150|52.5|379/383|DNA_pol_A| HM:PFM:REP 13->173|PF02739|2.1e-62|61.5|161/169|5_3_exonuc_N| HM:PFM:REP 294->422|PF09281|9.5e-60|61.2|129/138|Taq-exonuc| HM:PFM:REP 175->262|PF01367|2.4e-33|58.0|88/101|5_3_exonuc| GO:PFM:NREP 11 GO:PFM GO:0003677|"GO:DNA binding"|PF02739|IPR020046| GO:PFM GO:0008409|"GO:5'-3' exonuclease activity"|PF02739|IPR020046| GO:PFM GO:0003677|"GO:DNA binding"|PF01367|IPR020047| GO:PFM GO:0008409|"GO:5'-3' exonuclease activity"|PF01367|IPR020047| GO:PFM GO:0001882|"GO:nucleoside binding"|PF09281|IPR015361| GO:PFM GO:0003887|"GO:DNA-directed DNA polymerase activity"|PF09281|IPR015361| GO:PFM GO:0006260|"GO:DNA replication"|PF09281|IPR015361| GO:PFM GO:0006281|"GO:DNA repair"|PF09281|IPR015361| GO:PFM GO:0003677|"GO:DNA binding"|PF00476|IPR001098| GO:PFM GO:0003887|"GO:DNA-directed DNA polymerase activity"|PF00476|IPR001098| GO:PFM GO:0006260|"GO:DNA replication"|PF00476|IPR001098| RP:SCP:NREP 4 RP:SCP:REP 10->174|1bgxT2|7e-10|84.6|162/173|c.120.1.2| RP:SCP:REP 175->288|1bgxT1|5e-30|74.3|113/116|a.60.7.1| RP:SCP:REP 308->417|1bgxT3|5e-48|80.0|110/133|c.55.3.5| RP:SCP:REP 432->833|1bgxT4|e-152|87.9|398/406|e.8.1.1| HM:SCP:REP 1->174|1bgxT2|1.4e-59|50.3|173/173|c.120.1.2|1/1|PIN domain-like| HM:SCP:REP 175->291|1bgxT1|1e-35|51.7|116/0|a.60.7.1|1/1|5' to 3' exonuclease, C-terminal subdomain| HM:SCP:REP 295->424|1qtmA1|1.1e-35|35.4|130/0|c.55.3.5|1/1|Ribonuclease H-like| HM:SCP:REP 425->833|1qtmA2|8e-155|56.7|409/409|e.8.1.1|1/1|DNA/RNA polymerases| OP:NHOMO 1529 OP:NHOMOORG 1023 OP:PATTERN -------------------------------------------------------------------- 1211211111111122222-22112222222222222222222232221121232221112231232323111111111111222222111111111--1111111111111111111111111111111111111111111121112111111111111111111111111111111111112111111112222222332222222222222222321132142222222222222222222222222222111111111111111121111111111211111111111111111111111211111111111111111111112111111111111221111112112212122212111111111111111111111111111111111111111111111111-111131111111111111111111221111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-1121111111111121111112112211111111111111111111111111111111111222111232212222111111111111111111111111111112221122112222222222222222222221-1111211111122222222221222222-22222222222222222222222222222222222222222222222222221233323323222111111111111111112111111111111111111111111111111111111211111211111111111222122222222222222222222111111111111111111111111111112-11211111111211111111111111111111 33--431-E66---1---------------------------------------------------------------------------------------------52512222-2121222572526G2-4251112222211221122-72131212112212111311312244K4444364A7-552332111 ------11----------------------------------------------11-----1-121--11-------------------11-----1-------1---------1------1----------------1----------1-1--------1-------------- STR:NPRED 834 STR:RPRED 100.0 SQ:SECSTR cccccccccccTTcccccccTHHHHTTcccTTccccccccccccTTHHHHHHHGGGTccccccEccccccccccccGGGGTTTcccccccTTcTTGGGTHHHHHHHTTccccccccccHHHHHHHHHHHHHHHTcccccccccTTccTTccTTcccccccccccccTTHHHHTcccGGGTTTTTTccccccccccccccccccTTTTTGGGTTcccccccccccccHTTTcHHHHcccccTTcGGGcccccccccccccccccccccHHHHHHHHTTTTcccTTccccccccccccEEEcccccTTcccEEEcccccTTTccccEEEcccccEEEccccHHHHHHHccccccTTHHHHHHHHHHHTccccccccHHHHHHHHcTTcccTTHHHHHHcccccccHHHHHHHHHHHHHHHHHHHTTcHHHHHHHHTTHHHHHHHHHHHHHHcccccTTTHHHHHHHHHHHHHHHHHHHHHccccccccccHHHHTTTTTTccccccccccccccccGGGTcTTTTGGGTccTTHHHHTHHHHccccTTccccTTTcccTTTcccccEEEcccccccccEEEcccTTccccccTTTTTTGGGccccccccEEEEEEccHHHHHHHHTTTcTTHHHHHHHTccHHHHHHHHHHTccTTcccTTHHHHHHHHHHHTTccccHHHHHHHccccHHHHHHHHHHHHHHcHHHHHHHHHHTHHHHTTcccccccccccccGGGccccHHHHHHHHHHHTTHHHHTHHHHHHHTHHHHHHHHHHHHTcEEEEEETTEEEEEcETTTcHHHHHHHHHHHHccccccccccEEccEEccHHHHcc DISOP:02AL 1-7, 289-299| PSIPRED ccccccHHHccccEEEEEcHHHHHHHHHccccccccccccHHHHHHHHHHHHHHHHHccccEEEEEEEcccccHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHccccEEEEccccHHHHHHHHHHHHHHcccEEEEEcccHHHHHHHcccEEEEccccccccHHHHHHHHcccHHHHHHHHHHHccccccccccccccHHHHHHHHHHcccHHHHHHHHHHHccccHHHHHHHHHHHHHHcccccEEEccccccccHHHcccccHHHHHHHHHHHHHHHHHHHHHHcccccHHHHcccHHHHHHHHHHHHccccccEEcEEEEEEEccccccccHHHHHHccccccHHHHHHHHHHHHHHHcccccccccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccHHHHHHHHHHHccccccccccccccccccHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccEEEEEEEEcccccccccccccccccccccccccHHHcEEEccccccEEEEEEHHHHHHHHHHHHHccHHHHHHHHccccHHHHHHHHHHcccHHHccHHHHHHHHHHHHHHHHcccHHHHHHHHcccHHHHHHHHHHHHHHcHHHHHHHHHHHHHHHHcccEEcccccEEEccccccccHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccEEEEEEccEEEEEccHHHHHHHHHHHHHHHHHHHcccccEEEEccccccHHHHcc //