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Thermus thermophilus HB27 (tthe0)
Gene : AAS81120.1
DDBJ      :             polynucleotide phosphorylase
Swiss-Prot:PNP_THETH    RecName: Full=Polyribonucleotide nucleotidyltransferase;         EC=2.7.7.8;AltName: Full=Polynucleotide phosphorylase;         Short=PNPase;

Homologs  Archaea  35/68 : Bacteria  884/915 : Eukaryota  87/199 : Viruses  0/175   --->[See Alignment]
a.4.9b.40.4c.1.25d.101.1d.14.1d.51.1
:713 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   22->557 3gcmA PDBj e-131 49.1 %
:BLT:PDB   629->698 1sroA PDBj 1e-16 52.9 %
:RPS:PDB   16->585 1e3hA PDBj e-173 43.2 %
:RPS:PDB   566->698 2e3uA PDBj 4e-20 15.4 %
:RPS:SCOP  25->149 1e3hA2  d.14.1.4 * 2e-23 46.4 %
:RPS:SCOP  150->240 1e3hA5  d.101.1.1 * 6e-28 35.2 %
:RPS:SCOP  245->332 1e3hA1  a.4.9.1 * 1e-05 25.9 %
:RPS:SCOP  335->470 1e3hA3  d.14.1.4 * 2e-41 47.8 %
:RPS:SCOP  472->647 1l2qA  c.1.25.1 * 2e-35 19.1 %
:RPS:SCOP  629->698 1sroA  b.40.4.5 * 2e-22 52.9 %
:HMM:SCOP  3->149 1e3hA2 d.14.1.4 * 7.2e-50 49.7 %
:HMM:SCOP  150->243 1e3hA5 d.101.1.1 * 3e-32 51.1 %
:HMM:SCOP  231->338 1whuA_ a.4.9.1 * 1.1e-15 34.3 %
:HMM:SCOP  334->470 1e3hA3 d.14.1.4 * 4.9e-47 44.5 %
:HMM:SCOP  465->572 1udsA2 d.101.1.1 * 5.2e-29 41.3 %
:HMM:SCOP  552->647 1we8A_ d.51.1.1 * 1.3e-20 40.0 %
:HMM:SCOP  630->698 1go3E1 b.40.4.5 * 8.7e-21 55.9 %
:RPS:PFM   20->149 PF01138 * RNase_PH 5e-10 37.5 %
:RPS:PFM   153->213 PF03725 * RNase_PH_C 6e-09 62.3 %
:RPS:PFM   337->468 PF01138 * RNase_PH 2e-14 41.7 %
:RPS:PFM   483->647 PF09887 * DUF2114 2e-04 28.6 %
:RPS:PFM   631->695 PF00575 * S1 1e-17 60.0 %
:HMM:PFM   19->149 PF01138 * RNase_PH 1.9e-23 37.9 124/132  
:HMM:PFM   335->468 PF01138 * RNase_PH 1.2e-27 37.7 130/132  
:HMM:PFM   152->215 PF03725 * RNase_PH_C 5.6e-24 53.1 64/68  
:HMM:PFM   471->540 PF03725 * RNase_PH_C 2.6e-13 36.9 65/68  
:HMM:PFM   631->698 PF00575 * S1 1.4e-20 48.5 68/74  
:HMM:PFM   569->623 PF00013 * KH_1 6.7e-12 39.6 53/57  
:HMM:PFM   258->332 PF03726 * PNPase 3.3e-10 28.8 73/83  
:BLT:SWISS 1->713 PNP_THETH 0.0 100.0 %
:REPEAT 2|20->296|337->605
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS81120.1 GT:GENE AAS81120.1 GT:PRODUCT polynucleotide phosphorylase GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION 752877..755018 GB:FROM 752877 GB:TO 755018 GB:DIRECTION + GB:PRODUCT polynucleotide phosphorylase GB:PROTEIN_ID AAS81120.1 GB:DB_XREF GI:46196704 LENGTH 713 SQ:AASEQ MEGTPNVPQAHRYELTLAGRPLVLETGKYAKQASGSVLVRYADTVVLATAQASETPVEADFLPLTVEFEERHYAVGKIPGSFMRREGRPGEKAILSARMTDRPIRPLFPKGFRHEVQIIVTVLSADQKNPPDILGPIAASAALMLSDIPWEGPIAAVRVGLIGGSFVLNPTLQELEESQLDLVVAGSKEAILMVEAEAGEVDEETLVQALEFAHKEMQPILELQEAMARELAKPKMAWTPPESLPEEEKEALYRLALERGLSQVLQTASKGERSRALAEFAERLIAEALPKGEDGTPDEGKKPLYESAFDEVVRRELRRLVLEEGKRADGRGPKDLRPIWIEVDVLPRAHGSAVFTRGETQVLGTVTLGTGRDEQILDDLGIDETEKFLVHYNFPPFSTGEVRRLRGVSRREVGHGNLAKRALKAVMPKEEDFPYTIRVVGDVLESNGSSSMATVCAGCLALMDAGVPIRAPVAGVAMGLVWEENRAVILTDILGLEDALGDMDFKVAGTRKGVTALQMDNKVGGLPREVLKEALLQAREARLKILDLMETVLPAPRPELKPFAPRILSLKVPVEKIGLVIGPGGKNVRALEELGVEVDIEEDGTVRIYSSDLNAALEAKKRIEDLTREAKVGEIYEGTVTRITPFGAFISLFPGTEGLLHISQIAPGRVERVEDHLKVGDVIKVKVHRIDERGKIDLIRPELEGKIPPRRRK GT:EXON 1|1-713:0| SW:ID PNP_THETH SW:DE RecName: Full=Polyribonucleotide nucleotidyltransferase; EC=2.7.7.8;AltName: Full=Polynucleotide phosphorylase; Short=PNPase; SW:GN Name=pnp; SW:KW Cytoplasm; Nucleotidyltransferase; RNA-binding; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->713|PNP_THETH|0.0|100.0|713/713| GO:SWS:NREP 4 GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016779|"GO:nucleotidyltransferase activity"|Nucleotidyltransferase| GO:SWS GO:0003723|"GO:RNA binding"|RNA-binding| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| NREPEAT 1 REPEAT 2|20->296|337->605| SEG 311->324|evvrrelrrlvlee| SEG 362->371|vlgtvtlgtg| BL:PDB:NREP 2 BL:PDB:REP 22->557|3gcmA|e-131|49.1|528/544| BL:PDB:REP 629->698|1sroA|1e-16|52.9|70/76| RP:PDB:NREP 2 RP:PDB:REP 16->585|1e3hA|e-173|43.2|551/585| RP:PDB:REP 566->698|2e3uA|4e-20|15.4|130/166| RP:PFM:NREP 5 RP:PFM:REP 20->149|PF01138|5e-10|37.5|122/130|RNase_PH| RP:PFM:REP 153->213|PF03725|6e-09|62.3|61/68|RNase_PH_C| RP:PFM:REP 337->468|PF01138|2e-14|41.7|127/130|RNase_PH| RP:PFM:REP 483->647|PF09887|2e-04|28.6|154/448|DUF2114| RP:PFM:REP 631->695|PF00575|1e-17|60.0|65/74|S1| HM:PFM:NREP 7 HM:PFM:REP 19->149|PF01138|1.9e-23|37.9|124/132|RNase_PH| HM:PFM:REP 335->468|PF01138|1.2e-27|37.7|130/132|RNase_PH| HM:PFM:REP 152->215|PF03725|5.6e-24|53.1|64/68|RNase_PH_C| HM:PFM:REP 471->540|PF03725|2.6e-13|36.9|65/68|RNase_PH_C| HM:PFM:REP 631->698|PF00575|1.4e-20|48.5|68/74|S1| HM:PFM:REP 569->623|PF00013|6.7e-12|39.6|53/57|KH_1| HM:PFM:REP 258->332|PF03726|3.3e-10|28.8|73/83|PNPase| GO:PFM:NREP 10 GO:PFM GO:0000175|"GO:3'-5'-exoribonuclease activity"|PF01138|IPR001247| GO:PFM GO:0003723|"GO:RNA binding"|PF01138|IPR001247| GO:PFM GO:0006396|"GO:RNA processing"|PF01138|IPR001247| GO:PFM GO:0000175|"GO:3'-5'-exoribonuclease activity"|PF03725|IPR015847| GO:PFM GO:0003723|"GO:RNA binding"|PF03725|IPR015847| GO:PFM GO:0006396|"GO:RNA processing"|PF03725|IPR015847| GO:PFM GO:0000175|"GO:3'-5'-exoribonuclease activity"|PF01138|IPR001247| GO:PFM GO:0003723|"GO:RNA binding"|PF01138|IPR001247| GO:PFM GO:0006396|"GO:RNA processing"|PF01138|IPR001247| GO:PFM GO:0003723|"GO:RNA binding"|PF00575|IPR003029| RP:SCP:NREP 6 RP:SCP:REP 25->149|1e3hA2|2e-23|46.4|125/149|d.14.1.4| RP:SCP:REP 150->240|1e3hA5|6e-28|35.2|91/111|d.101.1.1| RP:SCP:REP 245->332|1e3hA1|1e-05|25.9|81/83|a.4.9.1| RP:SCP:REP 335->470|1e3hA3|2e-41|47.8|136/137|d.14.1.4| RP:SCP:REP 472->647|1l2qA|2e-35|19.1|173/457|c.1.25.1| RP:SCP:REP 629->698|1sroA|2e-22|52.9|70/76|b.40.4.5| HM:SCP:REP 3->149|1e3hA2|7.2e-50|49.7|147/149|d.14.1.4|1/2|Ribosomal protein S5 domain 2-like| HM:SCP:REP 150->243|1e3hA5|3e-32|51.1|94/111|d.101.1.1|1/2|Ribonuclease PH domain 2-like| HM:SCP:REP 231->338|1whuA_|1.1e-15|34.3|102/0|a.4.9.1|1/1|Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3| HM:SCP:REP 334->470|1e3hA3|4.9e-47|44.5|137/137|d.14.1.4|2/2|Ribosomal protein S5 domain 2-like| HM:SCP:REP 465->572|1udsA2|5.2e-29|41.3|104/105|d.101.1.1|2/2|Ribonuclease PH domain 2-like| HM:SCP:REP 552->647|1we8A_|1.3e-20|40.0|95/0|d.51.1.1|1/1|Eukaryotic type KH-domain (KH-domain type I)| HM:SCP:REP 630->698|1go3E1|8.7e-21|55.9|68/0|b.40.4.5|1/1|Nucleic acid-binding proteins| OP:NHOMO 1397 OP:NHOMOORG 1006 OP:PATTERN 111----11111111111-----1--------1-111-----------11-1111112211-11-1-1 1122222111111211111-111111111111111111112222121112212221121111211222221111111112211111111111111111111111112111111111111111111111111111113223311122111111111111111111111111111111111111122211211244333333334333333324444333433442244444431222222222222222222223111111111111111112211-2223333222333222222222213333333333333323333333225124222222232421332122243232222222222222132221111112111111111111111111111111111111111-11111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111121111111111111111111111111112211222122221111122111111111111111211111211111111111111111112111111111111111111111111111-1111111111111111111111111111-1111111111111111111111111111111--1---111111111111111111111111111111111111111111111111111111111122211111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111---------------------1222111111122 ------1---------------------------------------------------------1----1-----------11--1----------------------1121111-2111111112121691-13111-111111111112-11-1111---12113311242213-12J323222226-422221111 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 705 STR:RPRED 98.9 SQ:SECSTR ########ccEEEEEGGcEEEEEEEEccccTTccEEEEEEETTTEEEEEEEEcccccTTccccEEEEEEEcGGGGTcccccTTcccccccHHHHHHHHHHHHHHHHHccTTccccEEEEEEEEEccTTcccHHHHHHHHHHHHHHTTcccccccEEEEEEEETTEEEEcccHHHHTTEEEEEEEEEEcTHHHHHHTTcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccHHHHHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHHTTTTcccccHcTTcHHHHHHHHHHHHHHHHHHHHHHTcccTTcccTTccccEEEEEcccccccEEEEEEETTEEEEEEEEEEEEGGcEEcccccccccEEcEEEEEccGGGGTcccccccccHHHHHHHHHHHHHHGGGcccTTTccEEEEEEEEEEEccccHHHHHHHHHHHHHHHHTcccccccEEEEEEEEEEEEEEEEEcccccHHHHHccEEEEEEEccccEEEEEEEEccccccHHHHHHHHHHHHHHHHHHHHHHHHHcHcccccccTTccccccHHHHccccccccccccHHHHccGGGTcccHHHHHHHcTTccccccccHHHcccccccccccccHHHHccccEEEcccccEEccccccccccccccGcccccccHHHHccTccccccccccccccccEEEEccTTcGHHHHHHHH DISOP:02AL 1-7, 78-93, 372-381, 399-415, 699-713| PSIPRED ccccccccccEEEEEEEccEEEEEEEEEEEEccccEEEEEEcccEEEEEEEEccccccccccEEEEEEEccHHHHcccccccccccccccccEEEEEEHHHHHHHHHccHHHcccEEEEEEEEEccccccHHHHHHHHHHHHHHHccccccccEEEEEEEEEccEEEEcccHHHHHcccEEEEEEEccccEEEEEEccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccEEEEEEEEEcccccccEEEEEEEccEEEEEEEEcccccccccccccccccEEEEEEEEcccccccccccccccccHHHHHHHHHHHHHHHHHHcccccccEEEEEEEEEEEccccHHHHHHHHHHHHHHHcccHHHcccEEEEEEEEEEccccEEEEccHHHHHcccccEEEEEEccccEEEEEEEcccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccEEEEEEEEEEcccccccccccccEEEEEEEEEEEEEEEccccEEEEEccHHHHHHHHHHHHHHHHccccccEEEEEEEEEEccEEEEEEccccEEEEEEEEcccccccccHHEEEcccEEEEEEEEEcccccEEccHHHccccccccccc //