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Thermus thermophilus HB27 (tthe0)
Gene : AAS81368.1
DDBJ      :             conserved hypothetical protein
Swiss-Prot:NPD_THET2    RecName: Full=NAD-dependent deacetylase;         EC=3.5.1.-;AltName: Full=Regulatory protein SIR2 homolog;

Homologs  Archaea  35/68 : Bacteria  557/915 : Eukaryota  176/199 : Viruses  1/175   --->[See Alignment]
c.31.1
:254 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   17->237 1m2gA PDBj 1e-53 48.4 %
:RPS:PDB   17->241 2b4yA PDBj 2e-20 33.3 %
:RPS:SCOP  17->241 1iciA  c.31.1.5 * 4e-62 48.0 %
:HMM:SCOP  1->244 1j8fA_ c.31.1.5 * 2e-83 49.8 %
:RPS:PFM   22->196 PF02146 * SIR2 5e-34 46.5 %
:HMM:PFM   22->196 PF02146 * SIR2 1.6e-47 41.2 170/181  
:BLT:SWISS 17->254 NPD_THET2 e-117 100.0 %
:PROS 108->115|PS00369|PTS_HPR_HIS
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS81368.1 GT:GENE AAS81368.1 GT:PRODUCT conserved hypothetical protein GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION complement(1004121..1004885) GB:FROM 1004121 GB:TO 1004885 GB:DIRECTION - GB:PRODUCT conserved hypothetical protein GB:PROTEIN_ID AAS81368.1 GB:DB_XREF GI:46196953 LENGTH 254 SQ:AASEQ MERLEEARKRLEEAKRVAVLTGAGISKPSGIPTFRDAEGLWKNFNPLDYATPEAYARDPEKVWAWYAWRIQKVREAKPNPAHYALVELERRILSRGGSFLLVTQNVDGLHARAGSQNLVELHGNLLRARCEACGKRFPLPEAFAPPPFCPACGHRARPDVVWFGELLPEGAWERAERAFAEADFALVVGTSAEVEPAASLGRIAFASGAYLVEVNPEPTPLTPLAHLSLRTGAVEGMALLLPPSPEDQAEGHLS GT:EXON 1|1-254:0| SW:ID NPD_THET2 SW:DE RecName: Full=NAD-dependent deacetylase; EC=3.5.1.-;AltName: Full=Regulatory protein SIR2 homolog; SW:GN Name=npdA; OrderedLocusNames=TT_C1026; SW:KW Complete proteome; Cytoplasm; Hydrolase; Metal-binding; NAD; Zinc. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 17->254|NPD_THET2|e-117|100.0|238/254| GO:SWS:NREP 3 GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| PROS 108->115|PS00369|PTS_HPR_HIS|PDOC00318| SEG 2->16|erleearkrleeakr| SEG 137->151|fplpeafapppfcpa| SEG 169->185|egaweraerafaeadfa| BL:PDB:NREP 1 BL:PDB:REP 17->237|1m2gA|1e-53|48.4|217/249| RP:PDB:NREP 1 RP:PDB:REP 17->241|2b4yA|2e-20|33.3|216/257| RP:PFM:NREP 1 RP:PFM:REP 22->196|PF02146|5e-34|46.5|170/178|SIR2| HM:PFM:NREP 1 HM:PFM:REP 22->196|PF02146|1.6e-47|41.2|170/181|SIR2| GO:PFM:NREP 6 GO:PFM GO:0006342|"GO:chromatin silencing"|PF02146|IPR003000| GO:PFM GO:0006476|"GO:protein amino acid deacetylation"|PF02146|IPR003000| GO:PFM GO:0008270|"GO:zinc ion binding"|PF02146|IPR003000| GO:PFM GO:0016811|"GO:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"|PF02146|IPR003000| GO:PFM GO:0045449|"GO:regulation of transcription"|PF02146|IPR003000| GO:PFM GO:0070403|"GO:NAD binding"|PF02146|IPR003000| RP:SCP:NREP 1 RP:SCP:REP 17->241|1iciA|4e-62|48.0|221/256|c.31.1.5| HM:SCP:REP 1->244|1j8fA_|2e-83|49.8|237/0|c.31.1.5|1/1|DHS-like NAD/FAD-binding domain| OP:NHOMO 1251 OP:NHOMOORG 769 OP:PATTERN 11---11111111111-12222221--1---11----------------1---11111111---1--1 1-1-22-222211112211-12112211111222222111-1111122-111111121--12212211211111111-1-1111-11111111111---11111111111---------------1----1---1-11133---511------------------------------------11111---111111111111111111111111111222-1--111111111111111111111111111111111111111111112-1-1------------1--------------------------1----------1-1111111111111111111-11111111-1---121-11-112-111111-111-----11222---11111------------11111111--1-------------1111-1-11111111---------11--111------------------------------1111-1---12112122222122122222122222222--1111-22222--1---1----11----------221122111---11----1--11-11211212322-1--11111-2111111111--121--11-121-11111111111111111111111--1-21-------111111111111111-1-1111111111111111111111111111111111111111111111111111-111111111111-------------1122----11--1-12---11111111-112-2222121211--22433----------111111111111111111111111-------1111111--------1-1----------1--------------1111111111-1- 11--213-3111232222-33313232232222111222222211133232343113-22323121-1-1--222-----1112231--344234221111--221-359A997675112234277261DW8-869232363343133243215343454364944231115466-211C1-1124223144331-113 -------------------1----------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 227 STR:RPRED 89.4 SQ:SECSTR ################EEEEEcGGGGGGGTccccTTcTcHcTTccHHHHccHHHHHHcHHHHHHHHHHHHHHHHTccccHHHHHHHHHHHHHHTTTcEEEEEEcccccHHHHHTcccEEETTEEEEEEEETTTccEEEcccccccGGGTTcccccTEEEEccTTccccHHHHHHHHHHHHHccEEEEEccccccTTGGHHHHHHHHTTccEEEEEccccTTGGGccEEEEccHHHHHHHHTTT########### DISOP:02AL 249-250, 252-254| PSIPRED cHHHHHHHHHHHHcccEEEEEcccccccccccccccccccHHHccccccccHHHHHHcHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHcccEEEEEEEccccHHHHcccccEEEEEEcccEEEEcccccEEccHHHHcccccccccccEEcccEEEEcccccHHHHHHHHHHHHHccEEEEEccccEEccHHHHHHHHHHccccEEEEccccccccccEEEEEEccHHHHHHHHHHHHHHHHHHcccc //