[GTOP] [HELP] [ORGANISMS] [SEARCH] [SUMMARY]
Thermus thermophilus HB27 (tthe0)
Gene : AAS81422.1
DDBJ      :             phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase
Swiss-Prot:HIS2_THET2   RecName: Full=Histidine biosynthesis bifunctional protein hisIE;Includes:  RecName: Full=Phosphoribosyl-AMP cyclohydrolase;           Short=PRA-CH;           EC=3.5.4.19;Includes:  RecName: Full=Phosphoribosyl-ATP pyrophosphatase;           Short=PRA-PH;           EC=3.6.1.31;

Homologs  Archaea  54/68 : Bacteria  703/915 : Eukaryota  100/199 : Viruses  0/175   --->[See Alignment]
a.204.1b.168.1
:214 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   13->104 1zpsB PDBj 6e-20 46.7 %
:BLT:PDB   114->175 2a7wA PDBj 4e-08 42.6 %
:RPS:PDB   117->201 2a7wA PDBj 5e-15 32.5 %
:RPS:SCOP  3->108 1zpsA1  b.168.1.1 * 2e-30 41.5 %
:RPS:SCOP  117->202 1yvwA1  a.204.1.4 * 9e-20 36.0 %
:HMM:SCOP  1->121 1zpsA1 b.168.1.1 * 2.7e-39 55.4 %
:HMM:SCOP  113->203 2a7wA1 a.204.1.4 * 7.6e-25 50.5 %
:RPS:PFM   54->101 PF01502 * PRA-CH 1e-17 66.7 %
:RPS:PFM   124->175 PF01503 * PRA-PH 5e-07 58.0 %
:HMM:PFM   29->102 PF01502 * PRA-CH 3.2e-37 60.8 74/75  
:HMM:PFM   117->197 PF01503 * PRA-PH 9.4e-15 27.6 76/83  
:BLT:SWISS 1->214 HIS2_THET2 e-100 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS81422.1 GT:GENE AAS81422.1 GT:PRODUCT phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION 1049415..1050059 GB:FROM 1049415 GB:TO 1050059 GB:DIRECTION + GB:PRODUCT phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase GB:PROTEIN_ID AAS81422.1 GB:DB_XREF GI:46197007 LENGTH 214 SQ:AASEQ MDLSAVRFDEKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGETSGHTQEVVEVLLDCDGDAVVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYATIKERLRTLPEGSYVARMHHAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAADLLFHLLLTLAELGLTPEDLAKTLWERHRPRSPYDGSHGN GT:EXON 1|1-214:0| SW:ID HIS2_THET2 SW:DE RecName: Full=Histidine biosynthesis bifunctional protein hisIE;Includes: RecName: Full=Phosphoribosyl-AMP cyclohydrolase; Short=PRA-CH; EC=3.5.4.19;Includes: RecName: Full=Phosphoribosyl-ATP pyrophosphatase; Short=PRA-PH; EC=3.6.1.31; SW:GN Name=hisI; Synonyms=hisIE; OrderedLocusNames=TT_C1080; SW:KW Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;Histidine biosynthesis; Hydrolase; Multifunctional enzyme;Nucleotide-binding. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->214|HIS2_THET2|e-100|100.0|214/214| GO:SWS:NREP 7 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0000105|"GO:histidine biosynthetic process"|Histidine biosynthesis| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| SEG 34->53|realeetlrtrrstffsrsr| SEG 176->189|llfhllltlaelgl| BL:PDB:NREP 2 BL:PDB:REP 13->104|1zpsB|6e-20|46.7|92/128| BL:PDB:REP 114->175|2a7wA|4e-08|42.6|61/88| RP:PDB:NREP 1 RP:PDB:REP 117->201|2a7wA|5e-15|32.5|83/88| RP:PFM:NREP 2 RP:PFM:REP 54->101|PF01502|1e-17|66.7|48/75|PRA-CH| RP:PFM:REP 124->175|PF01503|5e-07|58.0|50/85|PRA-PH| HM:PFM:NREP 2 HM:PFM:REP 29->102|PF01502|3.2e-37|60.8|74/75|PRA-CH| HM:PFM:REP 117->197|PF01503|9.4e-15|27.6|76/83|PRA-PH| GO:PFM:NREP 4 GO:PFM GO:0000105|"GO:histidine biosynthetic process"|PF01502|IPR002496| GO:PFM GO:0004635|"GO:phosphoribosyl-AMP cyclohydrolase activity"|PF01502|IPR002496| GO:PFM GO:0000105|"GO:histidine biosynthetic process"|PF01503|IPR008179| GO:PFM GO:0004636|"GO:phosphoribosyl-ATP diphosphatase activity"|PF01503|IPR008179| RP:SCP:NREP 2 RP:SCP:REP 3->108|1zpsA1|2e-30|41.5|106/124|b.168.1.1| RP:SCP:REP 117->202|1yvwA1|9e-20|36.0|86/92|a.204.1.4| HM:SCP:REP 1->121|1zpsA1|2.7e-39|55.4|121/0|b.168.1.1|1/1|HisI-like| HM:SCP:REP 113->203|2a7wA1|7.6e-25|50.5|91/0|a.204.1.4|1/1|all-alpha NTP pyrophosphatases| OP:NHOMO 922 OP:NHOMOORG 857 OP:PATTERN ------1111111111-1111111211212211112211212111111111211-1-111-1----11 1111111111111111111-11111111111111111111111111111111111111--111111111111111111--11111111111111-----1-111111111---------------111111111111111111111121111111111111111111211211111111111111111111111-11-11111111111111111111111111111111111-11111111111111111-1----11-2---22--11----1-111-------211------------------------2----2----11-2122--2-2-1111121---1-1--1111111112111111111--11111111-----111111111111111111111111111111111111-1111111111111111111211111111111111111111111-----------------------------11111111111111111111111111111111111111111111111111111111131122112222222111111-1111111111111-212222121----111-11111111111-1-------11111111112111111111111111111111111111--111211111111111111111111111-1111111111111111111112111111111111111111111111111111-11111111111111-1-----111111211111111-11-----1111111111111111112122111111111--------111111111111111111111111111111111112222--------------------------------------1--1-111111 --------------11111111-1211111111111-11111111111111111-1111111111111---1111-1-1-1---1-11-11111111111111111-12------------------------------------------------------------------1111811111111111111----1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 197 STR:RPRED 92.1 SQ:SECSTR ############EEEEEEEETTTccEEEEEEEcHHHHHHHHHHcccEEEETTTcccHHHHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHHTTTTccHHHHHHHHHHHHHHHHHHHHHHHHHGGGccTTTcHHHHHHHHcHHHHHHHHHHHHHHHHHHHHTTcHHHHHHHHHHHHHHHHHHHHHTTccHHHHHHHHHHcHHcHcccc##### DISOP:02AL 200-214| PSIPRED ccccccccccccEEEEEEEEcccccEEEEEEccHHHHHHHHHccEEEEEEEccccccccccccccEEEEEEEEEcccccEEEEEEEEcccccccccccccccccccccccHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHccccccccccccc //