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Thermus thermophilus HB27 (tthe0)
Gene : AAS81497.1
DDBJ      :             phosphoribosylformylglycinamidine synthase
Swiss-Prot:PURL_THET8   RecName: Full=Phosphoribosylformylglycinamidine synthase 2;         EC=6.3.5.3;AltName: Full=Phosphoribosylformylglycinamidine synthase II;         Short=FGAM synthase II;

Homologs  Archaea  60/68 : Bacteria  755/915 : Eukaryota  61/199 : Viruses  0/175   --->[See Alignment]
d.139.1d.79.4
:725 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   20->554 2hs3A PDBj e-110 48.4 %
:RPS:PDB   14->666 3d54A PDBj 3e-91 40.2 %
:RPS:SCOP  14->189 1vk3A1  d.79.4.1 * 4e-40 50.6 %
:RPS:SCOP  194->368 1t3tA6  d.139.1.1 * 7e-36 22.3 %
:RPS:SCOP  397->551 1vk3A2  d.79.4.1 * 4e-44 39.3 %
:RPS:SCOP  604->702 1t3tA6  d.139.1.1 * 1e-08 19.4 %
:HMM:SCOP  3->190 1t3tA4 d.79.4.1 * 5.8e-50 35.8 %
:HMM:SCOP  188->414 1t3tA7 d.139.1.1 * 7.3e-53 38.1 %
:HMM:SCOP  387->552 1vk3A2 d.79.4.1 * 2.8e-44 47.5 %
:HMM:SCOP  555->723 1t3tA7 d.139.1.1 * 5.8e-39 42.3 %
:RPS:PFM   66->160 PF00586 * AIRS 2e-15 47.8 %
:RPS:PFM   204->320 PF02769 * AIRS_C 4e-07 40.4 %
:RPS:PFM   427->522 PF00586 * AIRS 9e-05 35.6 %
:HMM:PFM   204->341 PF02769 * AIRS_C 6e-27 30.6 134/151  
:HMM:PFM   559->694 PF02769 * AIRS_C 1.4e-19 40.3 134/151  
:HMM:PFM   66->160 PF00586 * AIRS 3.1e-28 48.9 90/96  
:HMM:PFM   429->524 PF00586 * AIRS 1e-16 36.6 93/96  
:BLT:SWISS 1->725 PURL_THET8 0.0 100.0 %
:REPEAT 2|6->329|380->682
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS81497.1 GT:GENE AAS81497.1 GT:PRODUCT phosphoribosylformylglycinamidine synthase GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION 1119931..1122108 GB:FROM 1119931 GB:TO 1122108 GB:DIRECTION + GB:PRODUCT phosphoribosylformylglycinamidine synthase GB:PROTEIN_ID AAS81497.1 GB:DB_XREF GI:46197083 LENGTH 725 SQ:AASEQ MEALAKEIGIPEGEYREIVQRLGREPNRVELLLFKVMWSEHCAYKNSRPLLKALPKEGEAVLQGPGENAGVVRVGEGWAVAFKIESHNHPSAVEPFQGAATGVGGILRDIMSMGARPIALLDSLRFGPPEEARSRYLLKGVVSGIAFYGNAIGVPTVGGDLYFHEGYRENPLVNAMCLGLLREEHLKRSRASLGRPIYYAGAKTGRDGIGGAAFASRELKEEKAEDRPAVQVGDPFLGKLLMEATLEAIELDLVEGVQDMGAAGLTSSLSELAHKSGLGVELHLDLVPTREEGMTPEELLLSESQERMVLVPKEGKEKALEEVFGRWGLDCVPVARTIPERVFRVLFRGEVVAEVPTEALAEAPTYVRVGREDPEVRRLRETPIPPLEADPQEVLRRLLASPNLASREAVYERYDHQVGTRTALLPGKGDAAVLWIKGTRLGVAAKVDQNPRYSRLHPRLGAMHALAEACRNVSVVGAKPLAYTDGLNLGSPETPEGYHELAETIAGLKEASEALGVPVVSGNVSLYNESGGKRIPPTAMVGVVGVLEVDKRAEMGFRRPGEVLLLIGEERGELGASEVLYLLTGKEFGHPPRLDLGREKAVQEAIRDLIQRGLTRTAHDVAEGGLLLALAEMTFPYGVGATVEVREEGLEALFGEAPSRVLFTVEKTRLQEATLLLEERGLPYRVLGETGGKSLTVLTPGGVLEWSLEELLSAWKAPLREVLDG GT:EXON 1|1-725:0| SW:ID PURL_THET8 SW:DE RecName: Full=Phosphoribosylformylglycinamidine synthase 2; EC=6.3.5.3;AltName: Full=Phosphoribosylformylglycinamidine synthase II; Short=FGAM synthase II; SW:GN Name=purL; OrderedLocusNames=TTHA1519; SW:KW ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;Purine biosynthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->725|PURL_THET8|0.0|100.0|725/725| GO:SWS:NREP 5 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006164|"GO:purine nucleotide biosynthetic process"|Purine biosynthesis| NREPEAT 1 REPEAT 2|6->329|380->682| SEG 561->575|gevllligeergelg| SEG 622->632|aegglllalae| SEG 704->713|lewsleells| BL:PDB:NREP 1 BL:PDB:REP 20->554|2hs3A|e-110|48.4|496/602| RP:PDB:NREP 1 RP:PDB:REP 14->666|3d54A|3e-91|40.2|567/583| RP:PFM:NREP 3 RP:PFM:REP 66->160|PF00586|2e-15|47.8|92/97|AIRS| RP:PFM:REP 204->320|PF02769|4e-07|40.4|114/148|AIRS_C| RP:PFM:REP 427->522|PF00586|9e-05|35.6|90/97|AIRS| HM:PFM:NREP 4 HM:PFM:REP 204->341|PF02769|6e-27|30.6|134/151|AIRS_C| HM:PFM:REP 559->694|PF02769|1.4e-19|40.3|134/151|AIRS_C| HM:PFM:REP 66->160|PF00586|3.1e-28|48.9|90/96|AIRS| HM:PFM:REP 429->524|PF00586|1e-16|36.6|93/96|AIRS| GO:PFM:NREP 2 GO:PFM GO:0003824|"GO:catalytic activity"|PF00586|IPR000728| GO:PFM GO:0003824|"GO:catalytic activity"|PF00586|IPR000728| RP:SCP:NREP 4 RP:SCP:REP 14->189|1vk3A1|4e-40|50.6|162/165|d.79.4.1| RP:SCP:REP 194->368|1t3tA6|7e-36|22.3|157/168|d.139.1.1| RP:SCP:REP 397->551|1vk3A2|4e-44|39.3|150/162|d.79.4.1| RP:SCP:REP 604->702|1t3tA6|1e-08|19.4|99/168|d.139.1.1| HM:SCP:REP 3->190|1t3tA4|5.8e-50|35.8|179/0|d.79.4.1|1/2|PurM N-terminal domain-like| HM:SCP:REP 188->414|1t3tA7|7.3e-53|38.1|215/217|d.139.1.1|1/2|PurM C-terminal domain-like| HM:SCP:REP 387->552|1vk3A2|2.8e-44|47.5|162/0|d.79.4.1|2/2|PurM N-terminal domain-like| HM:SCP:REP 555->723|1t3tA7|5.8e-39|42.3|168/217|d.139.1.1|2/2|PurM C-terminal domain-like| OP:NHOMO 887 OP:NHOMOORG 876 OP:PATTERN --11--1111111111-111111111111111111111111111111111111111121-1111--11 1111111111111111111-1111111111111111111111111111111111111111111111111111111111111111111111111111---11111-2-111---------------11111111111111111111111111111111111111111111111111111111111111111-1111111111111111111111111111111111111111111111111111111111111111-11111-1-11111111111111111111111111111111111111111111111111111111111112111111111111111111111111111111111111111111111111-1111111111111111111111111111111111-11111111111111111111111111111111111111111111111111111111111111111---------------1111111111-------------------1--------1----11---11---1---1---1121111111111111111111111111111111111111111111111-1111111111111-1-------11111--1111111111111111111111111111111-11111------11111111111111111-1111111111111-111111111111111111111111111111111111111111111111111--111111111111-1-1111111-111111111111111--1111111111111111111111111111111111111111111111------------1111111111--------1---------------------------1-11111111111 -----11-----11-------------111111--------------1111111-----1111-1-11-11-11------1--1--11-----1-1---1-------------1------------1-------------1-11----1----11--1-----2-------1---111------12--11111-21211 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 685 STR:RPRED 94.5 SQ:SECSTR #############THHHHHHHHcccccHHHHHHHHHHTccccccTTTHHHHGGGccTTEEHHccccccTTEEEccccEEEEEEEEEccHHHHHccHHHHHHHHHHHHHHHHTTTcEEEEEEEEEEEccccHHHcccccHHHHHHHHHHHGGGTccEEEEEEEEcTTcTTccEEEEEEEEEEEGGGccccccccccEEEEEEccccccccccHHHHHHHHHccccccccccccccHHHHHHHHHHHHHHHHTTcccEEEEccccTHHHHHTHHHHTTTcEEEEEGGGcccccTTccHHHHHccccccEEEEEEcTTccTTHHHHHHHTTcEEEEEEEEEcccEEEEEETTEEEEEEETHHHHccccccccccccHHHEEEEEEcHHHcccccccccccccccccccccHHHHTTccccTTccccccTTEcccEEcccTTccEEEEEEEEccHHHHHHcTTHHHHHHHHHHHHHHHTTTcEEEEEEccEEcccTTTcHHHHHHHHHHHHHHHHHHHccccEEEcccccccEETTEEcccEEcEEEEEEEcTTcccccTTccTTcEEEEEEccccTccccEEEEEEHcccccccccEEccccGGGcHHHHHHHHHHHTTTcEEEccTTcccHHHHHHHTTTcEEEEcccccEEEEEEEcccccccccEETTTHHHHHHHHHHHTccEEEEEEEEcccEEEE########################### PSIPRED cHHHHHHccccHHHHHHHHHHHcccccHHHHHHHHHHccHHHHHccHHHHHHHcccccccEEEcccccEEEEEEcccEEEEEEEcccccccccccHHHHHHEEEEEcHHHHccccEEEEEEEEEEccccccccHHHHHHHHHHHHHHHHHHHcccEEccEEEEcccccccEEEEEEEEEEEcHHHccccccccccEEEEEcccccccccHHHHHHHHHHcccccccccccccccHHHHHHHHHHHHHHHHccccEEEEcccccHHHHHHHHHHHHHccEEEEEcHHcccccccccHHHHHHcccccEEEEEEcHHHHHHHHHHHHHccccEEEEEEEEcccEEEEEEccEEEEEEcHHHHcccccEEcccccccccccccccccccccccHHHHHHHHHcccccccccccEEEccEEEcccEEEEcccccEEEEEEccccEEEEEEEccccccEEccHHHHHHHHHHHHHHHEEEEccEEEEEEEHHcccccccccHHHHHHHHHHHHHHHHHHHccEEEEcccEEEEccccccccccEEEEEEEEEccccEEcHHHcccccEEEEEcccccccHHHHHHHHHccccccccccccHHHHHHHHHHHHHHHHcccEEEEEEccccHHHHHHHHHHHccccEEEEEEccccHHHHHcccccEEEEEEcHHHHHHHHHHHHHccccEEEEEEEccccEEEEEccEEEEccHHHHHHHHHHHHHHHHcc //