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Thermus thermophilus HB27 (tthe0)
Gene : AAS81529.1
DDBJ      :             GMP synthase
Swiss-Prot:GUAA_THET2   RecName: Full=GMP synthase [glutamine-hydrolyzing];         EC=6.3.5.2;AltName: Full=Glutamine amidotransferase;AltName: Full=GMP synthetase;

Homologs  Archaea  64/68 : Bacteria  854/915 : Eukaryota  189/199 : Viruses  0/175   --->[See Alignment]
c.23.16c.26.2d.52.2
:503 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   1->503 2ywbC PDBj 0.0 99.8 %
:RPS:PDB   2->194 2a9vB PDBj 4e-45 28.8 %
:RPS:PDB   208->503 2dplA PDBj 1e-39 45.7 %
:RPS:SCOP  2->187 1gpmA2  c.23.16.1 * 5e-36 40.9 %
:RPS:SCOP  190->328 1gpmA1  c.26.2.1 * 2e-16 43.2 %
:RPS:SCOP  383->503 1gpmA3  d.52.2.1 * 2e-24 62.0 %
:HMM:SCOP  1->219 1l9xA_ c.23.16.1 * 1e-60 43.1 %
:HMM:SCOP  175->425 2nsyA_ c.26.2.1 * 1.7e-50 38.7 %
:HMM:SCOP  383->503 1gpmA3 d.52.2.1 * 1.8e-48 68.6 %
:RPS:PFM   28->183 PF00117 * GATase 6e-24 38.5 %
:RPS:PFM   211->241 PF03054 * tRNA_Me_trans 9e-04 51.6 %
:RPS:PFM   412->502 PF00958 * GMP_synt_C 3e-30 62.6 %
:HMM:PFM   3->182 PF00117 * GATase 5.8e-42 37.8 180/192  
:HMM:PFM   413->502 PF00958 * GMP_synt_C 5.7e-40 65.6 90/93  
:HMM:PFM   212->252 PF01171 * ATP_bind_3 9.1e-07 53.7 41/182  
:BLT:SWISS 1->503 GUAA_THET2 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS81529.1 GT:GENE AAS81529.1 GT:PRODUCT GMP synthase GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION 1152651..1154162 GB:FROM 1152651 GB:TO 1154162 GB:DIRECTION + GB:PRODUCT GMP synthase GB:NOTE glutamine-hydrolyzing GB:PROTEIN_ID AAS81529.1 GB:DB_XREF GI:46197115 LENGTH 503 SQ:AASEQ MVLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLKHRPQALILSGGPRSVFDPDAPRPDPRLFSSGLPLLGICYGMQLLAQELGGRVERAGRAEYGKALLTRHEGPLFRGLEGEVQVWMSHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYGVQFHPEVAHTPKGMQILENFLELAGAKRDWTPEHVLEELLREVRERAGKDRVLLAVSGGVDSSTLALLLAKAGVDHLAVFVDHGLLRLGEREEVEGALRALGVNLLVVDAKERFLKALKGVEDPEEKRKIIGREFVAAFSQVARERGPFRFLAQGTLYPDVIESAGGHGAAKIKSHHNVGGLPEDLEFELLEPFRLLFKDEVRELALLLGLPDTLRLRHPFPGPGLAVRVLGEVTEERLEILRRADDIFTSLLREWGLYEKVAQALAVLTPVRSVGVAGDERKYGYVLALRAVTTEDFMTADWARLPLEFLDEAARRITRRVPEIGRVVYDLTSKPPATIEWE GT:EXON 1|1-503:0| SW:ID GUAA_THET2 SW:DE RecName: Full=GMP synthase [glutamine-hydrolyzing]; EC=6.3.5.2;AltName: Full=Glutamine amidotransferase;AltName: Full=GMP synthetase; SW:GN Name=guaA; OrderedLocusNames=TT_C1187; SW:KW ATP-binding; Complete proteome; Glutamine amidotransferase;GMP biosynthesis; Ligase; Nucleotide-binding; Purine biosynthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->503|GUAA_THET2|0.0|100.0|503/503| GO:SWS:NREP 6 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0006541|"GO:glutamine metabolic process"|Glutamine amidotransferase| GO:SWS GO:0006177|"GO:GMP biosynthetic process"|GMP biosynthesis| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006164|"GO:purine nucleotide biosynthetic process"|Purine biosynthesis| SEG 13->24|rliarrlrelra| SEG 195->206|vleellrevrer| SEG 244->261|gllrlgereevegalral| SEG 342->358|lpedlefellepfrllf| SEG 365->377|lalllglpdtlrl| BL:PDB:NREP 1 BL:PDB:REP 1->503|2ywbC|0.0|99.8|466/466| RP:PDB:NREP 2 RP:PDB:REP 2->194|2a9vB|4e-45|28.8|191/195| RP:PDB:REP 208->503|2dplA|1e-39|45.7|267/287| RP:PFM:NREP 3 RP:PFM:REP 28->183|PF00117|6e-24|38.5|156/185|GATase| RP:PFM:REP 211->241|PF03054|9e-04|51.6|31/348|tRNA_Me_trans| RP:PFM:REP 412->502|PF00958|3e-30|62.6|91/93|GMP_synt_C| HM:PFM:NREP 3 HM:PFM:REP 3->182|PF00117|5.8e-42|37.8|180/192|GATase| HM:PFM:REP 413->502|PF00958|5.7e-40|65.6|90/93|GMP_synt_C| HM:PFM:REP 212->252|PF01171|9.1e-07|53.7|41/182|ATP_bind_3| GO:PFM:NREP 5 GO:PFM GO:0003824|"GO:catalytic activity"|PF00117|IPR000991| GO:PFM GO:0003922|"GO:GMP synthase (glutamine-hydrolyzing) activity"|PF00958|IPR001674| GO:PFM GO:0005524|"GO:ATP binding"|PF00958|IPR001674| GO:PFM GO:0006164|"GO:purine nucleotide biosynthetic process"|PF00958|IPR001674| GO:PFM GO:0006177|"GO:GMP biosynthetic process"|PF00958|IPR001674| RP:SCP:NREP 3 RP:SCP:REP 2->187|1gpmA2|5e-36|40.9|186/205|c.23.16.1| RP:SCP:REP 190->328|1gpmA1|2e-16|43.2|139/175|c.26.2.1| RP:SCP:REP 383->503|1gpmA3|2e-24|62.0|121/121|d.52.2.1| HM:SCP:REP 1->219|1l9xA_|1e-60|43.1|218/0|c.23.16.1|1/1|Class I glutamine amidotransferase-like| HM:SCP:REP 175->425|2nsyA_|1.7e-50|38.7|235/271|c.26.2.1|1/1|Adenine nucleotide alpha hydrolases-like| HM:SCP:REP 383->503|1gpmA3|1.8e-48|68.6|121/0|d.52.2.1|1/1|GMP synthetase C-terminal dimerisation domain| OP:NHOMO 2332 OP:NHOMOORG 1107 OP:PATTERN 2213--3233333323-322222343334355333333333332123323333333223222331-22 2211242222312122211-1122121111111222124211111211222222222122111111223311111222112222212222322311-11111121211311-------1111111222322222222222222212223222232333232222222223222222222222233333221222333333332333333222222333222323333333322222222222222222233121111111-1112211111111113332222222222222222222222222222222222211222111123123111111111122322222212122222233322121323222121222333311111343112132111233333333333-44344443223122222222222223242222222313222222222222132221111111111---------------111113232322222222222322222222222222222222222222222222222332222222222222222222222133432222222221323222232222334352222222222222222222222222223332322233333333333333333333342-22322-1----33443333333333333-333333333333333333335344333333233333333333333333333213323333233331123221222222222321111221222232222222222222222232222322222222222222322223333222223332222333333333323222122222211111-1-1------1-------------1------1-21121222233 11-1111-311-1222212122213221112222122132223222212322322222222222222222222222212222222222-23222141111312222-2412111111112111112-11251-11211111-11-1111-1111111112651111111113322211191111233432821154221 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 503 STR:RPRED 100.0 SQ:SECSTR cEEEEEccccTTcHHHHHHHHTTccccEEETTccGGGGHTTTccEEEEccccGGGTGGGHHHHHHHHHHccccEEEETHHHHHHHHHTTcEEEEEEEEEEEEEEEEEcccGGGTTcccEEEEEEEEEEEEEcccTTEEEEEEcccccccEEEEccccEEEEcccTTcTTcTTHHHHHHHHHHHHHHHHHHHHHcHHHHHHHHHHHHHHHcEEEEEccccHHHHHHHHHHHHHHHHTTccGGGEEEEEcccccHHHHHHHHHTcEEEEccTHHHHHHHHHHTTcGGGGTcccccHHHHHHHHHHHHHHHHHHHHHHHHTEEEEEcccHHHHHHTcccccccTccccTTcccEEccTTccHHHHHHHHHHHHHHccccHHHHHHHHHHHHHccTTcccHHHHHHHHHHHHHHHcccHHHHHHHHHHHHccTTcccccTTccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHTTcHHHHHTccccccccTTccccTTTTHHHH PSIPRED cEEEEEccccHHHHHHHHHHHcccEEEEEcccccHHHHHHccccEEEEcccccccHHccccHHHHHHHcccccEEEEcHHHHHHHHHcccEEEEcccccccEEEEEEcccHHHccccccEEEEEEEEEEEEEcccccEEEEEEccccEEEEEEccccEEEEEccccccccccHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHccccEEEEEEcccccHHHHHHHHHHHcccEEEEEEccccccccHHHHHHHHHHHccccEEEEcHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHccccEEEEcccccHHHHccccccccEEEEcccccccccccccEEEcHHHHHHHHHHHHHHHHccccHHHHcccccccccccEEEEccccHHHHHHHHHHHHHHHHHHHHcccHHHHHHccEEEccccccccccccccccEEEEEEEEEEccccccccHHccHHHHHHHHHHHHcccccccEEEEEcccccccccccc //