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Thermus thermophilus HB27 (tthe0)
Gene : AAS81892.1
DDBJ      :             2-isopropylmalate synthase/Homocitrate synthase
Swiss-Prot:HOSC_THET2   RecName: Full=Homocitrate synthase;         EC=2.3.3.14;

Homologs  Archaea  56/68 : Bacteria  633/915 : Eukaryota  122/199 : Viruses  0/175   --->[See Alignment]
c.1.10
:376 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   1->320 2ztjA PDBj e-169 100.0 %
:RPS:PDB   2->332 3bg9A PDBj 2e-43 15.7 %
:RPS:SCOP  1->282 1sr9A2  c.1.10.5 * 4e-46 21.9 %
:HMM:SCOP  1->283 1sr9A2 c.1.10.5 * 5.6e-68 37.1 %
:RPS:PFM   12->241 PF00682 * HMGL-like 7e-27 40.6 %
:HMM:PFM   12->244 PF00682 * HMGL-like 1.9e-65 37.8 230/237  
:BLT:SWISS 1->376 HOSC_THET2 0.0 100.0 %
:PROS 11->27|PS00815|AIPM_HOMOCIT_SYNTH_1
:PROS 192->205|PS00816|AIPM_HOMOCIT_SYNTH_2
:COIL
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS81892.1 GT:GENE AAS81892.1 GT:PRODUCT 2-isopropylmalate synthase/Homocitrate synthase GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION complement(1471090..1472220) GB:FROM 1471090 GB:TO 1472220 GB:DIRECTION - GB:PRODUCT 2-isopropylmalate synthase/Homocitrate synthase GB:PROTEIN_ID AAS81892.1 GB:DB_XREF GI:46197479 LENGTH 376 SQ:AASEQ MREWKIIDSTLREGEQFEKANFSTQDKVEIAKALDEFGIEYIEVTTPVASPQSRKDAEVLASLGLKAKVVTHIQCRLDAAKVAVETGVQGIDLLFGTSKYLRAAHGRDIPRIIEEAKEVIAYIREAAPHVEVRFSAEDTFRSEEQDLLAVYEAVAPYVDRVGLADTVGVATPRQVYALVREVRRVVGPRVDIEFHGHNDTGCAIANAYEAIEAGATHVDTTILGIGERNGITPLGGFLARMYTLQPEYVRRKYKLEMLPELDRMVARMVGVEIPFNNYITGETAFSHKAGMHLKAIYINPEAYEPYPPEVFGVKRKLIIASRLTGRHAIKARAEELGLHYGEEELHRVTQHIKALADRGQLTLEELDRILREWITA GT:EXON 1|1-376:0| SW:ID HOSC_THET2 SW:DE RecName: Full=Homocitrate synthase; EC=2.3.3.14; SW:GN Name=lys20; OrderedLocusNames=TT_C1550; SW:KW Amino-acid biosynthesis; Complete proteome; Cytoplasm;Lysine biosynthesis; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->376|HOSC_THET2|0.0|100.0|376/376| GO:SWS:NREP 4 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0009085|"GO:lysine biosynthetic process"|Lysine biosynthesis| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 11->27|PS00815|AIPM_HOMOCIT_SYNTH_1|PDOC00643| PROS 192->205|PS00816|AIPM_HOMOCIT_SYNTH_2|PDOC00643| COIL:NAA 30 COIL:NSEG 1 COIL:REGION 343->372| SEG 179->190|vrevrrvvgprv| SEG 334->346|eelglhygeeelh| BL:PDB:NREP 1 BL:PDB:REP 1->320|2ztjA|e-169|100.0|312/312| RP:PDB:NREP 1 RP:PDB:REP 2->332|3bg9A|2e-43|15.7|319/601| RP:PFM:NREP 1 RP:PFM:REP 12->241|PF00682|7e-27|40.6|224/237|HMGL-like| HM:PFM:NREP 1 HM:PFM:REP 12->244|PF00682|1.9e-65|37.8|230/237|HMGL-like| GO:PFM:NREP 1 GO:PFM GO:0003824|"GO:catalytic activity"|PF00682|IPR000891| RP:SCP:NREP 1 RP:SCP:REP 1->282|1sr9A2|4e-46|21.9|279/310|c.1.10.5| HM:SCP:REP 1->283|1sr9A2|5.6e-68|37.1|280/0|c.1.10.5|1/1|Aldolase| OP:NHOMO 1361 OP:NHOMOORG 811 OP:PATTERN ---4--3323333333-43333322--212213333333333333333446643331-1-12-13-22 11321-------------------1------1-1111---2222--1-1-----------111-11-1121--------12-222222222222---11--2-1211232---------------33223333334222333333223423323322111111222254431111111111112323333112211111121111111111111111122222--11111143-2222221212222111111--------------------111-1--------11111-1111-----------------111111111-43-4311111111113133----3-2--2--443353333-333324--1-321111-----332332224333311111111111-11111211111-2112111111113312122243222221111111112211332-----------------------------2-11-1-----4333242-1111112211111223111111111222222431421231111111111111111132-3322232133223-333333333333313221111111111-----------2111221121111-1111111111111111111111---1121-11--111212111111111111-11-1111111111111111121211111111111111111111111111111-11111111111111-1-----1111211--111111-111-1111------1---3-11-1---11----2----11--11-1111111111111111111111111111111141333333--------------------------------------3--21222322 ------1-----1121111111121211111111111111111111111223222211111112212212232223222222222211-13111111111111333-121---------------------------------------------------------------1-2111G1111121211432221113 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 376 STR:RPRED 100.0 SQ:SECSTR TcccEEEEcTTTHHHHHHcTcccHHHHHHTHHHHHHHcTTcEEEEEccHHHHHHHTcccEEEEEETTTcTccccccHHHHHHHHHHTccEEEEEcccccHHHHHHHHcHHHHHHHHHHHHTcEEEEEEEccccTTcccccTTcHHHHHHHHHHHHHcccEEEEEcTTccccHHHHHHHHHHHHHHcTTcccEEEEccTTcccTHHHHHHHHHTTccEEEEccGGGccTTccccHHHHHHHHTTccccTTcccccHHHHHHHHHHHHHHHHHGGGGcGGGTTcccccTTHHHHcccHHHHHHHHHHHHHHHTTcccccHHHHHHHHHHHHHHHEEEGGGccHHHHHHHHHHHTTcTTEEEEEEGGGGTccccEEEEE PSIPRED cccEEEEEcccccHHHcccccccHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHccccccEEEEHHccHHHHHHHHHccccEEEEEccccHHHHHHHcccHHHHHHHHHHHHHHHHHHcccEEEEEEccccccccHHHHHHHHHHHHccccEEEEEcccccccHHHHHHHHHHHHHHcccccEEEEEEcccccHHHHHHHHHHHccccEEEEEccccccccccccHHHHHHHHHHHHcccccccccHHHHHHHHHHHHHHHccccccccccccccHHHHHcccHHHHHHccHHHcccccHHHccccEEEEEEccHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHcc //