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Thermus thermophilus HB27 (tthe0)
Gene : AAS82049.1
DDBJ      :             formate-tetrahydrofolate ligase
Swiss-Prot:FTHS_THET2   RecName: Full=Formate--tetrahydrofolate ligase;         EC=6.3.4.3;AltName: Full=Formyltetrahydrofolate synthetase;         Short=FHS;         Short=FTHFS;

Homologs  Archaea  7/68 : Bacteria  350/915 : Eukaryota  187/199 : Viruses  0/175   --->[See Alignment]
c.37.1
:543 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   9->540 1fp7B PDBj e-129 49.4 %
:RPS:PDB   9->540 1eg7A PDBj 4e-57 47.5 %
:RPS:SCOP  9->540 1eg7A  c.37.1.10 * 5e-45 47.5 %
:HMM:SCOP  7->540 1eg7A_ c.37.1.10 * 4e-210 59.0 %
:RPS:PFM   7->541 PF01268 * FTHFS e-152 53.7 %
:HMM:PFM   5->541 PF01268 * FTHFS 2.8e-227 59.2 537/555  
:BLT:SWISS 1->543 FTHS_THET2 0.0 100.0 %
:PROS 92->102|PS00721|FTHFS_1
:PROS 317->328|PS00722|FTHFS_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS82049.1 GT:GENE AAS82049.1 GT:PRODUCT formate-tetrahydrofolate ligase GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION complement(1620845..1622476) GB:FROM 1620845 GB:TO 1622476 GB:DIRECTION - GB:PRODUCT formate-tetrahydrofolate ligase GB:PROTEIN_ID AAS82049.1 GB:DB_XREF GI:46197636 LENGTH 543 SQ:AASEQ MIVKEDLLPIEEVAAKLGLDRDRLYLYGPHMAKVLGEPPKAKGKLVLVTAITPTPAGEGKTTTAIGLVDALWRLGKRAALALREPSLGPVFGVKGGATGGGKARVEPRHEINLHFTGDFHAVTSAVNLLNALLDNHLHQGNELGIDPRRIELKRAIDMNDRALRHIVLGLGGKAHGVPREGGFELTVASEVMALMSLARDFQDLKRRLGRMRVAFTHEGKPVYAEDLMAVGAMAALLRQAFLPNLVQTAEGNPAFIHMGPFGNIAHGTNSLRASLFALGLADLVVQEAGFATDLGLEKFMNVVARTTGLVPEAVVLVATIRALRYHGGQDAYGMPDPKAVKAGLANLEKHVENVELFGYKPVIALNRFPSDAPEEIALVRAFAEERGLPFAPSEVYAQGGEGGLELAERVLEALDLPHAYRPLYPLEASLEAKVEAIATRVYGAEGVEWSEEAKRALKAAKKEGCEALPVVVAKAATSLSDNPRLRGRPRGFTVRVTDLRCRLGAGFVVVYMGGIETLPGLPKTPQAFGIDVDEEGNIRGMDY GT:EXON 1|1-543:0| SW:ID FTHS_THET2 SW:DE RecName: Full=Formate--tetrahydrofolate ligase; EC=6.3.4.3;AltName: Full=Formyltetrahydrofolate synthetase; Short=FHS; Short=FTHFS; SW:GN Name=fhs; OrderedLocusNames=TT_C1707; SW:KW ATP-binding; Complete proteome; Ligase; Nucleotide-binding;One-carbon metabolism. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->543|FTHS_THET2|0.0|100.0|543/543| GO:SWS:NREP 4 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006730|"GO:one-carbon metabolic process"|One-carbon metabolism| PROS 92->102|PS00721|FTHFS_1|PDOC00595| PROS 317->328|PS00722|FTHFS_2|PDOC00595| SEG 88->103|gpvfgvkggatgggka| SEG 127->138|nllnalldnhlh| SEG 399->414|ggegglelaervleal| SEG 451->463|eeakralkaakke| BL:PDB:NREP 1 BL:PDB:REP 9->540|1fp7B|e-129|49.4|530/548| RP:PDB:NREP 1 RP:PDB:REP 9->540|1eg7A|4e-57|47.5|531/549| RP:PFM:NREP 1 RP:PFM:REP 7->541|PF01268|e-152|53.7|533/553|FTHFS| HM:PFM:NREP 1 HM:PFM:REP 5->541|PF01268|2.8e-227|59.2|537/555|FTHFS| GO:PFM:NREP 3 GO:PFM GO:0004329|"GO:formate-tetrahydrofolate ligase activity"|PF01268|IPR000559| GO:PFM GO:0005524|"GO:ATP binding"|PF01268|IPR000559| GO:PFM GO:0009396|"GO:folic acid and derivative biosynthetic process"|PF01268|IPR000559| RP:SCP:NREP 1 RP:SCP:REP 9->540|1eg7A|5e-45|47.5|531/549|c.37.1.10| HM:SCP:REP 7->540|1eg7A_|4e-210|59.0|532/0|c.37.1.10|1/1|P-loop containing nucleoside triphosphate hydrolases| OP:NHOMO 743 OP:NHOMOORG 544 OP:PATTERN ------------------------1---1-1--------------1---------------111---- 1----11----111--------------------------------11----111--1----11--1----111111111123-----1111-111----1-----------------------------------1111111211----------------------------------------1-111-1-111111111111111--111-111---2-111111111-1111111111111111111212111111121111111111111111111211121111111111111222222222222221111111111211111111111111111111111111111122211111111111111111------1--111-----------------------1111111111--1--11111111111-111121111112--------1---1--------------------------------1----1---------------------------------------1-------------1-1-11111111-------1111-1-1-----1-------------1-11-11------------------------11---------11111--111111111111-----------------1---------------------------------------1--------------------------1------------------------1----111---1-----------------1-----------------------------11111111111121-----------------1--------------1-1------------------1---1111111111111111 ----111-21--1111111111111111111111111111-111111111111111111111222222122121222-3222222122-12111111111111212-12123334332222222552822Q2-3232222322322222222242222313311143411332111111H1111111521111112113 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 539 STR:RPRED 99.3 SQ:SECSTR ##cccHHHcHHHHHHTTTccGGGEEEcccccEEEcTHHTccccEEEEEEEccccTTcccHHHHHHHHHHHHHHTTccEEEEEcccccTHHHHTTccccEETTEEEEcHHHHHTTTTcHHHHHHHHHHHHHHHHHHHHHTTcTTcccGGGccccEEEccccGGGccEEEccccTTccccEEEcEEEGGGcHHHHHHHHcccHHHHHHHHHTcEEEEcTTccEEETGGGTcHHHHHHHTTTTTccEEEEETTccEEEEccccccccccccccHHHHHHHHHHccEEEEEccccTTTHHHHHHHTHHHHHTccccEEEEEEcHHHHHHTTTGGGTTcccHHHHHHHHHHHHHHHHHHHTTTccEEEEEEccTTccHHHHHHHHHHTTTcEEEEEcEcTTTGGGGGHHHHHHHHHHHHHccccccccccTTccHHHHHHHHHHHTTcccEEEEcHHHHHHHHHHHHTTcTTccEEEEccTTcccccTTccccccccEEEEcccEEETTTEEEEEcccTTccccccccccGGGTcEEccccEEccc## PSIPRED cccccccccHHHHHHHccccHHHcccccccEEEEEcccccccccEEEEEEccccccccccccHHHHHHHHHHHcccEEEEEEccccccccccccccccccccEEEEcHHHccccccccHHHHHHHHHHHHHHHHHHHHccccccccccEEEEEEEcccccHHHHEEEEccccccccEEEcccEEEEHHHHHHHHHHHHccHHHHHHHHHcEEEEEEcccccEEEEEcccHHHHHHHHHHHccccEEEEEcccEEEEEccccHHHHccccHHHHHHHHHHHccEEEEcccccccccccEEEEEEcccccccccEEEEEEcHHHHHHcccccccccccHHHHHHHHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHHccccEEEEEHHHHccHHHHHHHHHHHHHHcccccccccccccccHHHHHHHHHHHHcccccEEEcHHHHHHHHHHHHcccccccEEEEEccccccccHHHcccccccEEEEEEEEEEccccEEEEEEccccccccccccccHHccEEcccccEEcccc //