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Thermus thermophilus HB27 (tthe0)
Gene : AAS82099.1
DDBJ      :             2-oxoisovalerate dehydrogenase alpha subunit
Swiss-Prot:ODBA_THET2   RecName: Full=2-oxoisovalerate dehydrogenase subunit alpha;         EC=1.2.4.4;AltName: Full=Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain;         Short=BCKDH E1-alpha;

Homologs  Archaea  23/68 : Bacteria  592/915 : Eukaryota  192/199 : Viruses  0/175   --->[See Alignment]
c.36.1
:367 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   6->367 1umdA PDBj 0.0 98.6 %
:RPS:PDB   16->365 3dvaA PDBj 2e-52 39.7 %
:RPS:SCOP  6->367 1um9A  c.36.1.11 * 1e-43 86.1 %
:HMM:SCOP  6->367 1umdA_ c.36.1.11 * 1.2e-110 41.4 %
:RPS:PFM   35->309 PF00676 * E1_dh 1e-46 42.3 %
:HMM:PFM   43->341 PF00676 * E1_dh 3.4e-93 39.1 297/300  
:BLT:SWISS 1->367 ODBA_THET2 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS82099.1 GT:GENE AAS82099.1 GT:PRODUCT 2-oxoisovalerate dehydrogenase alpha subunit GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION complement(1667032..1668135) GB:FROM 1667032 GB:TO 1668135 GB:DIRECTION - GB:PRODUCT 2-oxoisovalerate dehydrogenase alpha subunit GB:PROTEIN_ID AAS82099.1 GB:DB_XREF GI:46197687 LENGTH 367 SQ:AASEQ MVKETHRFEPFTEEPIRLIGEEGEWLGDFPLDLEGEKLRRLYRDMLAARMLDERYTILIRTGKTSFIAPAAGHEAAQVAIAHAIRPGFDWVFPYYRDHGLALALGIPLKELFGQMLATKADPNKGRQMPEHPGSKALNFFTVASPIASHVPPAAGAAISMKLLRTGQVAVCTFGDGATSEGDWYAGINFAAVQGAPAVFVCENNFYAISVDYRHQTHSPTIADKAHAFGIPGYLVDGMDVLASYYVVKEAVERARRGEGPSLVELRVYRYGPHSSADDDSRYRPKEEVAFWRKKDPIPRFRRFLEARGLWNEEWEEDVREEIRAELERGLKEAEEAGPVPPEWMFADVFAEKPWHLLRQEALLKEEL GT:EXON 1|1-367:0| SW:ID ODBA_THET2 SW:DE RecName: Full=2-oxoisovalerate dehydrogenase subunit alpha; EC=1.2.4.4;AltName: Full=Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; Short=BCKDH E1-alpha; SW:GN OrderedLocusNames=TT_C1757; SW:KW Complete proteome; Magnesium; Metal-binding; Oxidoreductase;Thiamine pyrophosphate. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->367|ODBA_THET2|0.0|100.0|367/367| GO:SWS:NREP 3 GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| SEG 312->327|eeweedvreeiraele| BL:PDB:NREP 1 BL:PDB:REP 6->367|1umdA|0.0|98.6|362/362| RP:PDB:NREP 1 RP:PDB:REP 16->365|3dvaA|2e-52|39.7|340/365| RP:PFM:NREP 1 RP:PFM:REP 35->309|PF00676|1e-46|42.3|265/298|E1_dh| HM:PFM:NREP 1 HM:PFM:REP 43->341|PF00676|3.4e-93|39.1|297/300|E1_dh| GO:PFM:NREP 2 GO:PFM GO:0008152|"GO:metabolic process"|PF00676|IPR001017| GO:PFM GO:0016624|"GO:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"|PF00676|IPR001017| RP:SCP:NREP 1 RP:SCP:REP 6->367|1um9A|1e-43|86.1|331/331|c.36.1.11| HM:SCP:REP 6->367|1umdA_|1.2e-110|41.4|362/362|c.36.1.11|1/1|Thiamin diphosphate-binding fold (THDP-binding)| OP:NHOMO 1621 OP:NHOMOORG 807 OP:PATTERN 11----1-2121222---111---3221--22----------------------------2111---- 11214-------1-22222-2---32222221333324643435122211113352241144312272322-----------5---1-111--1--21132333343233222222222222221---------2-45522---2311111111111111111111311212111211211112212211-323333333332333333353343333355233222222242122222222222222233322-1-22-1---111111111111111111111112211111-1111111111111111112111111111-1---1111111-1-1111---------3------1-------11213-13--411411111222112112112144443343343-11111211231122212163224323212325222222322222222133112111111111111--11111111111111111-25B31-1-112222321111111141111-32122221--111-1-----2421--11----1----------1211-2-2----1-----212-23312221223-2----------------------1112211-11-221122211122111112111123---21--------------1-------------------------------11--12------------------------------------------2222222222--2-1---------------11111-1---3-3333121112221-----------------1-----11-112211111111---------11111----------111111-1-11111111111111-------------121 22--222-622-22222222233333322221222222222122222223223222222222211111111111111-1111111111-23222222222222224129265333332312333331727R3-6363222332311232241222122234324322645524223232T2224574862653442223 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 367 STR:RPRED 100.0 SQ:SECSTR ccEEHHHHHHHccccEccccTTcccccGGcccccHHHHHHHHHHHHHHHHHHHHHHHHHHTTccccccccTTcHHHHHHHHTTccTTccEEEccTTcHHHHHHTTccHHHHHHHHHTcGGGGcccTTcccccccccTTcccccccTTHHHHHHHHHHHHHHHHTccccEEEEEETGGGGcHHHHHHHHHHHHTTccEEEEEEEccEETTEEGGGTccccccGGGGGGTTccEEEEETTcHHHHHHHHHHHHHHHHTTcccEEEEEEccccccccccTTcTccccccTTGGGccccHHHHHHHHHHTTTcccHHHHHHHHHHHHHHHHHHHHHHHHcccccHHHHHHTTcccccHHHHHHHHHHHHHH DISOP:02AL 1-2, 277-285| PSIPRED ccccccccccccccEEEEEcccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHcccEEEcccccccHHHHHHHHHHHccccccEEEEccHHHHHHHHccccHHHHHHHHHHccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHHHcccEEEEEEccccccccccHHccccccHHHHHHHccccEEEEccccHHHHHHHHHHHHHHHHcccccEEEEEEEEEcccccccccccccccHHHHHHHHcccHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHcccccHHHHHHHHHHHHHc //