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Thermus thermophilus HB27 (tthe0)
Gene : AAS82273.1
DDBJ      :             DNA topoisomerase I
Swiss-Prot:             

Homologs  Archaea  66/68 : Bacteria  900/915 : Eukaryota  67/199 : Viruses  1/175   --->[See Alignment]
e.10.1g.39.1g.41.3
:824 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   19->633 2gaiA PDBj e-100 42.3 %
:BLT:PDB   712->736 1dgtB PDBj 2e-04 60.0 %
:RPS:PDB   15->589 1cy2A PDBj e-133 39.3 %
:RPS:PDB   591->663 3a43A PDBj 3e-07 23.8 %
:RPS:PDB   675->724 3a43A PDBj 7e-04 21.6 %
:RPS:SCOP  18->590 1d6mA  e.10.1.1 * e-122 23.2 %
:RPS:SCOP  587->636 1yuaA1  g.41.3.3 * 1e-13 20.0 %
:RPS:SCOP  635->680 1imlA2  g.39.1.3 * 7e-04 30.0 %
:RPS:SCOP  659->717 1yuaA1  g.41.3.3 * 4e-04 11.1 %
:HMM:SCOP  15->602 1mw9X_ e.10.1.1 * 9.1e-191 48.5 %
:HMM:SCOP  572->634 1yuaA1 g.41.3.3 * 5.9e-11 36.5 %
:HMM:SCOP  635->680 1yuaA1 g.41.3.3 * 4.7e-09 41.9 %
:RPS:PFM   18->110 PF01751 * Toprim 1e-08 41.2 %
:RPS:PFM   140->568 PF01131 * Topoisom_bac 1e-64 46.8 %
:RPS:PFM   589->625 PF01396 * zf-C4_Topoisom 3e-09 56.8 %
:RPS:PFM   632->665 PF01396 * zf-C4_Topoisom 2e-09 61.8 %
:HMM:PFM   140->571 PF01131 * Topoisom_bac 1.2e-133 48.1 395/404  
:HMM:PFM   589->625 PF01396 * zf-C4_Topoisom 5.3e-16 45.9 37/39  
:HMM:PFM   633->666 PF01396 * zf-C4_Topoisom 2e-16 52.9 34/39  
:HMM:PFM   673->705 PF01396 * zf-C4_Topoisom 1.9e-06 43.8 32/39  
:HMM:PFM   17->123 PF01751 * Toprim 4.1e-27 47.9 94/96  
:HMM:PFM   709->730 PF06677 * Auto_anti-p27 7.6e-06 50.0 22/41  
:BLT:SWISS 15->703 TOP1_BACHD e-144 43.4 %
:PROS 305->327|PS00396|TOPOISOMERASE_I_PROK
:REPEAT 2|594->637|638->677
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS82273.1 GT:GENE AAS82273.1 GT:PRODUCT DNA topoisomerase I GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION 1840330..1842804 GB:FROM 1840330 GB:TO 1842804 GB:DIRECTION + GB:PRODUCT DNA topoisomerase I GB:PROTEIN_ID AAS82273.1 GB:DB_XREF GI:46197861 LENGTH 824 SQ:AASEQ MPKSAKRRASQPTGAETLVVVESPAKARSIQKMLGPGYEVRASLGHVVDLPERSLGVDVERDFAPTYEVKKDKKPVVEELKRAAEGKRLLIATDPDREGEAIGWHVARLLGRDPKEPLRVEFHEITPRVVRQAVEAPRPIDQNLVDAQQARRVLDRLLGYNLSPLLSLEFRKRALSAGRVQSVALRLVVEREEAIEAFRPEEYWVLRGVFAVEGGEAPLVATLHEVEGKRLWTGQGEKEGRLHLASEAEAHALAEALRKGSYRVAQVEVRERRKAPPPPFTTSTLQQAASSRLGYTAARTMRIAQRLYEGVDLPEGTVGLITYMRTDSVRVAPEAVAAAREVIGKAFGPEYLPEAPRAYKNRREGVQDAHEAIRPTDPQRTPESVRPYLSEEEYRLYELIWRRFLASQMRDALYEQTAVTLADLEGRYAFRASGSVLRFEGYLRAWGRDAEEEEEPPVPAVPEGVPARLEEVLEERRFTEPPPRYTDASLVKTMEELGIGRPSTYAPTLETLEKRGYVARKGRTLFPTPLGRQVTAYLRERFPQVVAYEFTARMEERLDEVEEGRVPWPKVVWEFYEPFLGELAQVPKKTCPECGRPLELKVSRYGQFLGCTGYPECTYTEPLERREAEPIGEACPKCGRPLLRKEGRYGAFIACSGYPECDYTRDDGTPTGHTCPKCGGRVLEKRSRKGRPYYKCENNACDFLSFYPLLEEACPACGWPLVKKGEKALCLNPACPEHEPSLLPAPKEAKKGRSRGKGKPPLAPPKDWEELVPFLPGLSPEERRAVEALARGEALAEEEARLARRALFKLRMRKGKARKEPVRA GT:EXON 1|1-824:0| BL:SWS:NREP 1 BL:SWS:REP 15->703|TOP1_BACHD|e-144|43.4|664/690| PROS 305->327|PS00396|TOPOISOMERASE_I_PROK|PDOC00333| NREPEAT 1 REPEAT 2|594->637|638->677| SEG 68->81|evkkdkkpvveelk| SEG 157->168|llgynlspllsl| SEG 242->257|lhlaseaeahalaeal| SEG 329->342|vrvapeavaaarev| SEG 388->399|ylseeeyrlyel| SEG 450->467|aeeeeeppvpavpegvpa| SEG 750->759|kkgrsrgkgk| SEG 781->813|eerravealargealaeeearlarralfklrmr| BL:PDB:NREP 2 BL:PDB:REP 19->633|2gaiA|e-100|42.3|562/581| BL:PDB:REP 712->736|1dgtB|2e-04|60.0|25/660| RP:PDB:NREP 3 RP:PDB:REP 15->589|1cy2A|e-133|39.3|537/557| RP:PDB:REP 591->663|3a43A|3e-07|23.8|63/138| RP:PDB:REP 675->724|3a43A|7e-04|21.6|47/138| RP:PFM:NREP 4 RP:PFM:REP 18->110|PF01751|1e-08|41.2|85/110|Toprim| RP:PFM:REP 140->568|PF01131|1e-64|46.8|400/407|Topoisom_bac| RP:PFM:REP 589->625|PF01396|3e-09|56.8|37/39|zf-C4_Topoisom| RP:PFM:REP 632->665|PF01396|2e-09|61.8|34/39|zf-C4_Topoisom| HM:PFM:NREP 6 HM:PFM:REP 140->571|PF01131|1.2e-133|48.1|395/404|Topoisom_bac| HM:PFM:REP 589->625|PF01396|5.3e-16|45.9|37/39|zf-C4_Topoisom| HM:PFM:REP 633->666|PF01396|2e-16|52.9|34/39|zf-C4_Topoisom| HM:PFM:REP 673->705|PF01396|1.9e-06|43.8|32/39|zf-C4_Topoisom| HM:PFM:REP 17->123|PF01751|4.1e-27|47.9|94/96|Toprim| HM:PFM:REP 709->730|PF06677|7.6e-06|50.0|22/41|Auto_anti-p27| GO:PFM:NREP 12 GO:PFM GO:0003677|"GO:DNA binding"|PF01131|IPR013497| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01131|IPR013497| GO:PFM GO:0005694|"GO:chromosome"|PF01131|IPR013497| GO:PFM GO:0006265|"GO:DNA topological change"|PF01131|IPR013497| GO:PFM GO:0003677|"GO:DNA binding"|PF01396|IPR013498| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01396|IPR013498| GO:PFM GO:0005694|"GO:chromosome"|PF01396|IPR013498| GO:PFM GO:0006265|"GO:DNA topological change"|PF01396|IPR013498| GO:PFM GO:0003677|"GO:DNA binding"|PF01396|IPR013498| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01396|IPR013498| GO:PFM GO:0005694|"GO:chromosome"|PF01396|IPR013498| GO:PFM GO:0006265|"GO:DNA topological change"|PF01396|IPR013498| RP:SCP:NREP 4 RP:SCP:REP 18->590|1d6mA|e-122|23.2|547/603|e.10.1.1| RP:SCP:REP 587->636|1yuaA1|1e-13|20.0|50/65|g.41.3.3| RP:SCP:REP 635->680|1imlA2|7e-04|30.0|40/48|g.39.1.3| RP:SCP:REP 659->717|1yuaA1|4e-04|11.1|58/65|g.41.3.3| HM:SCP:REP 15->602|1mw9X_|9.1e-191|48.5|561/0|e.10.1.1|1/1|Prokaryotic type I DNA topoisomerase| HM:SCP:REP 572->634|1yuaA1|5.9e-11|36.5|63/65|g.41.3.3|1/2|Zinc beta-ribbon| HM:SCP:REP 635->680|1yuaA1|4.7e-09|41.9|43/65|g.41.3.3|2/2|Zinc beta-ribbon| OP:NHOMO 1444 OP:NHOMOORG 1034 OP:PATTERN 332323323333333322222122111111111112211111111111122222222222211123-- 1121111111111111111-11111111111111111111111111111111111111111111111111111111211111231322232212111--1121111121211111111111111111111111111111111111132321111111111111111222211111111111111111222112122222222222222232112122213312121222223211111111111111111111211111211111111112211111111111111111111111111111111111111111111111111121133222222212223111222111111112133341211131122111111111111111111111112111111111111111-11112112112111111111111111111111111111111111111111111111111111111111111111111111111111111111112111111211111111111111151111211111-214111-1112111112111211111111311112111221122221111111111111121111111111211111232121111221333322312222223222222222232222221-111111--11122232212222222222-3222222233222222222323322323222222222332322222222112-222222222222--1111111111111112332232222223322211211111121122212211111112121111111111232222222322331111111111211211211111111111111111111111-111-1111111111111112112121222111 ----11--212-------------------------------------------------------1--------------11-------1----1------1----11-21211111-1111-42-1-161-11-1---1--1--1--111-----11----21--1112-11-11118111122-12-111-1---- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------1---- STR:NPRED 730 STR:RPRED 88.6 SQ:SECSTR ######EEccccccccEEEEEccHHHHHHHHTTccTTEEEEEcccccEEcccHHHTEETTTTTEEccEEcTTcHHHHHHHHHHHHHccEEEcccccHHHHHHHHHHHHHHcccGGGEEEcccccccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTcTTccccTTHHHHHHHHHHHHHHHHTccccEEEEEEEEEEcTTccEEEEEEcccEGGEEEEEEETTEEcccccHHHHHHHHHHHHHHHccEEEEEEEEEEEEEcccccccHHHHHHHHHHHHcccHHHHHHHHHHHHHTccTTGGGETcccccccccccccHHHHHHHHHHHHHHTcGGGccccccccccccccccccccccccccTTccGGGcTcTccHHHHHHHHHHHHHHHHHTcccEEEEEEEEEEEEccTTEEEEEEEEEEEEcGGGGGcccccccccccTTcEEcTTcEEEEEEEEEEEEEccccccccHHHHHHHHHHTTcccTTTHHHHHHHTTTTTcEEEccccEEEcHHHHHHHHHHHHHcHHHHcHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHHcccccccGGGTcccEEEEEEEccTTTcccHHHHHHHHHHcccccEEEEEcccEEcHHHTTcccEEEEccHHHHHHHHHHHHHTTTTccTTccHHHHTTTHHHHcccEEEcEEEccHccHHHHccHHHHHHHHHHHHHccccccccTTcT######################################################################################## DISOP:02AL 1-17, 271-272, 357-366, 747-760, 813-824| PSIPRED ccccccccccccccccEEEEEEccHHHHHHHHHcccccEEEEEEcEEEcccccccccccHHHccccccccHHHHHHHHHHHHHHHccEEEEcccccccHHHHHHHHHHHHccccccEEEEEEEcccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccEEcccHHHHHHHHHHHHHHHHccccccEEEEEEEEEEccccEEEEEEEEEcccccccccccccccccccccHHHHHHHHHHHHcccEEEEEEEEEEEEEcccccccHHHHHHHHHHHHcccHHHHHHHHHHHHccccccccccccccccccccccccHHHHHHHHHHHHHHHcHHHHHHHHHccccccccccccccccccccccccHHHHHHcccHHHHHHHHHHHHHHHHHHccccEEEEEEEEEEEccccEEEEEEEEEEEEccHHHHccccccccccccccccccccEEEEEEEEEEcccccccccccHHHHHHHHHHcccccccccHHHHHHHHHcccEEEEccEEEEcHHHHHHHHHHHHHcHHHccHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHccccHHHcccEEEEEcccccEEEccccccccccccccccccccccccccccccEEEEEEccccEEEEEcccccccccccccccccEEccccccEEEEEEcccccEEEEEEcccccEEccccccccccHHccccEEEEccccccccccccccccccccccHHccccccccccccccccccccHHHccccccccHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHcccccccccc //