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Thermus thermophilus HB27 (tthe0)
Gene : mutM
DDBJ      :mutM         formamidopyrimidine-DNA glycosylase mutM
Swiss-Prot:FPG_THET8    RecName: Full=Formamidopyrimidine-DNA glycosylase;         Short=Fapy-DNA glycosylase;         EC=3.2.2.23;AltName: Full=DNA-(apurinic or apyrimidinic site) lyase mutM;         Short=AP lyase mutM;         EC=4.2.99.18;

Homologs  Archaea  0/68 : Bacteria  720/915 : Eukaryota  10/199 : Viruses  0/175   --->[See Alignment]
a.156.1b.113.1g.39.1
:267 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   2->267 1ee8A PDBj e-134 100.0 %
:RPS:PDB   2->267 1ee8A PDBj 1e-71 88.0 %
:RPS:SCOP  2->122 1ee8A2  b.113.1.1 * 5e-27 90.1 %
:RPS:SCOP  123->211 1ee8A1  a.156.1.2 * 2e-22 77.5 %
:RPS:SCOP  212->267 1ee8A3  g.39.1.8 * 1e-23 100.0 %
:HMM:SCOP  2->124 1ee8A2 b.113.1.1 * 1.2e-33 50.4 %
:HMM:SCOP  121->212 1tdhA1 a.156.1.2 * 1.9e-33 64.1 %
:HMM:SCOP  212->267 1ee8A3 g.39.1.8 * 1.6e-16 50.0 %
:RPS:PFM   2->99 PF01149 * Fapy_DNA_glyco 2e-12 53.6 %
:RPS:PFM   122->210 PF06831 * H2TH 2e-15 50.6 %
:RPS:PFM   236->263 PF06827 * zf-FPG_IleRS 1e-05 64.3 %
:HMM:PFM   122->213 PF06831 * H2TH 4.2e-30 47.8 92/93  
:HMM:PFM   2->105 PF01149 * Fapy_DNA_glyco 2.3e-28 49.0 104/116  
:HMM:PFM   236->263 PF06827 * zf-FPG_IleRS 6.7e-11 46.4 28/30  
:BLT:SWISS 1->267 FPG_THET8 e-134 100.0 %
:PROS 239->263|PS01242|ZF_FPG_1
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAS81796.1 GT:GENE mutM GT:PRODUCT formamidopyrimidine-DNA glycosylase mutM GT:DATABASE GIB00176CH01 GT:ORG tthe0 GB:ACCESSION GIB00176CH01 GB:LOCATION 1372708..1373511 GB:FROM 1372708 GB:TO 1373511 GB:DIRECTION + GB:GENE mutM GB:PRODUCT formamidopyrimidine-DNA glycosylase mutM GB:PROTEIN_ID AAS81796.1 GB:DB_XREF GI:46197383 GB:GENE:GENE mutM LENGTH 267 SQ:AASEQ MPELPEVETTRRRLRPLVLGQTLRQVVHRDPARYRNTALAEGRRILEVDRRGKFLLFALEGGVELVAHLGMTGGFRLEPTPHTRAALVLEGRTLYFHDPRRFGRLFGVRRGDYREIPLLLRLGPEPLSEAFAFPGFFRGLKESARPLKALLLDQRLAAGVGNIYADEALFRARLSPFRPARSLTEEEARRLYRALREVLAEAVELGGSTLSDQSYRQPDGLPGGFQTRHAVYGREGLPCPACGRPVERRVVAGRGTHFCPTCQGEGP GT:EXON 1|1-267:0| SW:ID FPG_THET8 SW:DE RecName: Full=Formamidopyrimidine-DNA glycosylase; Short=Fapy-DNA glycosylase; EC=3.2.2.23;AltName: Full=DNA-(apurinic or apyrimidinic site) lyase mutM; Short=AP lyase mutM; EC=4.2.99.18; SW:GN Name=mutM; Synonyms=fpg; OrderedLocusNames=TTHA1806; SW:KW 3D-structure; Complete proteome; DNA damage; DNA repair; DNA-binding;Glycosidase; Hydrolase; Lyase; Metal-binding; Multifunctional enzyme;Zinc; Zinc-finger. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->267|FPG_THET8|e-134|100.0|267/267| GO:SWS:NREP 9 GO:SWS GO:0006974|"GO:response to DNA damage stimulus"|DNA damage| GO:SWS GO:0006281|"GO:DNA repair"|DNA repair| GO:SWS GO:0003677|"GO:DNA binding"|DNA-binding| GO:SWS GO:0016798|"GO:hydrolase activity, acting on glycosyl bonds"|Glycosidase| GO:SWS GO:0008152|"GO:metabolic process"|Glycosidase| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0016829|"GO:lyase activity"|Lyase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| PROS 239->263|PS01242|ZF_FPG_1|PDOC00956| SEG 100->111|rrfgrlfgvrrg| SEG 183->202|lteeearrlyralrevlaea| BL:PDB:NREP 1 BL:PDB:REP 2->267|1ee8A|e-134|100.0|266/266| RP:PDB:NREP 1 RP:PDB:REP 2->267|1ee8A|1e-71|88.0|266/266| RP:PFM:NREP 3 RP:PFM:REP 2->99|PF01149|2e-12|53.6|97/118|Fapy_DNA_glyco| RP:PFM:REP 122->210|PF06831|2e-15|50.6|89/92|H2TH| RP:PFM:REP 236->263|PF06827|1e-05|64.3|28/30|zf-FPG_IleRS| HM:PFM:NREP 3 HM:PFM:REP 122->213|PF06831|4.2e-30|47.8|92/93|H2TH| HM:PFM:REP 2->105|PF01149|2.3e-28|49.0|104/116|Fapy_DNA_glyco| HM:PFM:REP 236->263|PF06827|6.7e-11|46.4|28/30|zf-FPG_IleRS| GO:PFM:NREP 11 GO:PFM GO:0003684|"GO:damaged DNA binding"|PF01149|IPR012319| GO:PFM GO:0003906|"GO:DNA-(apurinic or apyrimidinic site) lyase activity"|PF01149|IPR012319| GO:PFM GO:0006284|"GO:base-excision repair"|PF01149|IPR012319| GO:PFM GO:0008270|"GO:zinc ion binding"|PF01149|IPR012319| GO:PFM GO:0016799|"GO:hydrolase activity, hydrolyzing N-glycosyl compounds"|PF01149|IPR012319| GO:PFM GO:0003684|"GO:damaged DNA binding"|PF06831|IPR015886| GO:PFM GO:0003906|"GO:DNA-(apurinic or apyrimidinic site) lyase activity"|PF06831|IPR015886| GO:PFM GO:0006289|"GO:nucleotide-excision repair"|PF06831|IPR015886| GO:PFM GO:0008270|"GO:zinc ion binding"|PF06831|IPR015886| GO:PFM GO:0016799|"GO:hydrolase activity, hydrolyzing N-glycosyl compounds"|PF06831|IPR015886| GO:PFM GO:0003824|"GO:catalytic activity"|PF06827|IPR010663| RP:SCP:NREP 3 RP:SCP:REP 2->122|1ee8A2|5e-27|90.1|121/121|b.113.1.1| RP:SCP:REP 123->211|1ee8A1|2e-22|77.5|89/89|a.156.1.2| RP:SCP:REP 212->267|1ee8A3|1e-23|100.0|56/56|g.39.1.8| HM:SCP:REP 2->124|1ee8A2|1.2e-33|50.4|121/121|b.113.1.1|1/1|N-terminal domain of MutM-like DNA repair proteins| HM:SCP:REP 121->212|1tdhA1|1.9e-33|64.1|92/115|a.156.1.2|1/1|S13-like H2TH domain| HM:SCP:REP 212->267|1ee8A3|1.6e-16|50.0|56/56|g.39.1.8|1/1|Glucocorticoid receptor-like (DNA-binding domain)| OP:NHOMO 831 OP:NHOMOORG 730 OP:PATTERN -------------------------------------------------------------------- 122121122221-132233-321121333332333332321311411212233232221132222222222-----------3----------------------1------------------1-----------11-1111111111111111111111111111111111111111111111111---111111111111111111211111111111111111111122111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111----------------------------1--112211111111-------3-21111111111111121111111111111111-1-1111111111111111111111111111111111111111111111111111111111-1111----1-1111111-11-1111111111111111111111111111111111111111111111111111111111111111111111111111111111---1111111111121211111111212-1--------------------------111111111111111111111111111111111-111-1------11112121111111111-1111111111111111111111121111211111111111111111111111-111111111111---1-----111111111111111111111111-111111111111111111111111111111111111112111111111111111111111112222111-----------------111111-1111111111111111111-----------1- -------------------------------------------------------------1-----------------------------------------------------------------------------------------------------1-------------11----12211---1------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 266 STR:RPRED 99.6 SQ:SECSTR #ccHHHHHHHHHHHHHHHTTcEEEEEEcccTTTEEcGGGGTTEEEEEEEEETTEEEEEETTTEEEEEEcTTTcEEEccccTTEEEEEEEcccEEEEEcTTcccEEEEEETTccTTcTHHHHccccTTcTTccHHHHHHHHHTccccHHHHHHHccccTTccHHHHHHHHHHTTccccccGGGccHHHHHHHHHHHHHHHHHHHHTTcccccccccccTTccccccGGGcccTTcTTcccTTTccccEEEEccccEEEEcTTTTTccc DISOP:02AL 265-267| PSIPRED ccccHHHHHHHHHHHHHHcccEEEEEEEccccccHHHHHHcccEEEEEEEcccEEEEEEccccEEEEEEccEEEEEEEcccccEEEEEEcccEEEEEEcccccEEEEEccccHHHHHHHHHcccccccccccHHHHHHHHHcccccHHHHHHcccEEEEccHHHHHHHHHHHcccHHHHcccccHHHHHHHHHHHHHHHHHHHHHcccEEcccccccccccccccccEEEEEccccccccccccEEEEEEEcccEEEEccccccccc //